Sulfamethizole

Modify Date: 2024-01-02 10:14:41

Sulfamethizole structure	Common Name	Sulfamethizole
	CAS Number	144-82-1	Molecular Weight	270.331
	Density	1.6±0.1 g/cm3	Boiling Point	504.9±52.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₀N₄O₂S₂	Melting Point	210 °C
	MSDS	Chinese USA	Flash Point	259.1±30.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Sulfamethizole

Sulfamethizole is a sulfathiazole antibacterial agent.Target: AntibacterialSulfamethizole is a sulfathiazole antibacterial agent. Sulfamethizole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Sulfamethizole, an inhibitor of dihydropteroate synthetase and the formation of folic acid, inhibited bioluminescence more than growth [1]. Treatment with sulfamethizole resulted in a significant reduction in bacterial counts in all samples from a susceptible strain (MIC, 128 micro g/ml) and a resistant strain (MIC, 512 micro g/ml). Infection with a sulII gene-positive strain (MIC, >2,048 micro g/ml) could not be treated with sulfamethizole, as no effect could be demonstrated in the urine, bladder, or kidneys [2].

Name	sulfamethizole
Synonym	More Synonyms

Description	Sulfamethizole is a sulfathiazole antibacterial agent.Target: AntibacterialSulfamethizole is a sulfathiazole antibacterial agent. Sulfamethizole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Sulfamethizole, an inhibitor of dihydropteroate synthetase and the formation of folic acid, inhibited bioluminescence more than growth [1]. Treatment with sulfamethizole resulted in a significant reduction in bacterial counts in all samples from a susceptible strain (MIC, 128 micro g/ml) and a resistant strain (MIC, 512 micro g/ml). Infection with a sulII gene-positive strain (MIC, >2,048 micro g/ml) could not be treated with sulfamethizole, as no effect could be demonstrated in the urine, bladder, or kidneys [2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1 Research Areas >> Infection
References	[1]. Watanabe, H. and J.W. Hastings, Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta, 1990. 1017(3): p. 229-34. [2]. Kerrn, M.B., N. Frimodt-Moller, and F. Espersen, Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother, 2003. 47(3): p. 1002-9.

Description

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

Research Areas >> Infection

References

[1]. Watanabe, H. and J.W. Hastings, Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta, 1990. 1017(3): p. 229-34.

[2]. Kerrn, M.B., N. Frimodt-Moller, and F. Espersen, Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother, 2003. 47(3): p. 1002-9.

Density	1.6±0.1 g/cm3
Boiling Point	504.9±52.0 °C at 760 mmHg
Melting Point	210 °C
Molecular Formula	C₉H₁₀N₄O₂S₂
Molecular Weight	270.331
Flash Point	259.1±30.7 °C
Exact Mass	270.024506
PSA	134.59000
LogP	0.51
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.687
Storage condition	2-8°C

Sulfamethizole MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP0875000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(5-methyl-1,3,4-thiadiazol-2-yl)-

CAS REGISTRY NUMBER :: 144-82-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C9-H10-N4-O2-S2

MOLECULAR WEIGHT :: 270.35

WISWESSER LINE NOTATION :: T5NN DSJ CMSWR DZ& E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4444 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3668 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6000 mg/kg/4W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumor types after systemic administration not seen spontaneously

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Mold - Aspergillus nidulans

DOSE/DURATION :: 1 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974 *** REVIEWS *** TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(1),2,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83544 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83544 No. of Facilities: 19 (estimated) No. of Industries: 2 No. of Occupations: 15 No. of Employees: 1635 (estimated) No. of Female Employees: 255 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R43
Safety Phrases	S36/37
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	WP0875000
HS Code	2935009090

N-[4-[[(5-methy...

CAS#:39719-87-4

~71%

Sulfamethizole

CAS#:144-82-1

Literature: Ahad, Ali Md.; Zuohe, Song; Du-Cuny, Lei; Moses, Sylvestor A.; Zhou, Li Li; Zhang, Shuxing; Powis, Garth; Meuillet, Emmanuelle J.; Mash, Eugene A. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 2046 - 2054

N-(5-methyl-1,3...

CAS#:349621-24-5

~99%

Sulfamethizole

CAS#:144-82-1

Literature: PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHARPE, Arlene, H.; BUTTE, Manish, J.; OYAMA, Shinji Patent: WO2011/82400 A2, 2011 ; Location in patent: Page/Page column 52 ;

4-Acetamidobenz...

CAS#:121-60-8

Sulfamethizole

CAS#:144-82-1

Literature: Recueil des Travaux Chimiques des Pays-Bas, , vol. 62, p. 207 Archiv der Pharmazie (Weinheim, Germany), , vol. 284, p. 53,57

nosyl chloride

CAS#:98-74-8

Sulfamethizole

CAS#:144-82-1

Literature: WO2011/82400 A2, ;

2-Amino-5-methy...

CAS#:108-33-8

4-Acetamidobenz...

CAS#:121-60-8

Sulfamethizole

CAS#:144-82-1

Literature: CH230860 , ;

(1E)-3-amino-1-...

CAS#:2302-95-6

4-Acetamidobenz...

CAS#:121-60-8

Sulfamethizole

CAS#:144-82-1

Literature: US2447702 , ;

2-Amino-5-methy...

CAS#:108-33-8

nosyl chloride

CAS#:98-74-8

Sulfamethizole

CAS#:144-82-1

Literature: US2358031 , ; CH231190 , ;

Acetyl chloride

CAS#:75-36-5

Sulfamethizole

CAS#:144-82-1

Literature: DE840544 , ; DRP/DRBP Org.Chem.

Precursor 7
CAS#:39719-87-4 N-[4-[[(5-methy... CAS#:349621-24-5 N-(5-methyl-1,3... CAS#:121-60-8 4-Acetamidobenz... CAS#:98-74-8 nosyl chloride
CAS#:108-33-8 2-Amino-5-methy... CAS#:2302-95-6 (1E)-3-amino-1-... CAS#:75-36-5 Acetyl chloride
DownStream 4
CAS#:29817-74-1 Benzenesulfonam... CAS#:29821-96-3 Benzenesulfonam... CAS#:29822-02-4 Benzenesulfonam... CAS#:39719-87-4 N-[4-[[(5-methy...

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

MFCD00053363

4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Sulfamethizole

Sulfarine

EINECS 205-641-1

Sulphamethizole

Benzenesulfonamide, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)-

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China
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China
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China
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China
Product Name: Sulfamethizole
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Sulfamethizole

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