AG-120

Modify Date: 2024-01-02 08:42:07

AG-120 structure	Common Name	AG-120
	CAS Number	1448347-49-6	Molecular Weight	582.961
	Density	1.5±0.1 g/cm3	Boiling Point	854.3±65.0 °C at 760 mmHg
	Molecular Formula	C₂₈H₂₂ClF₃N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	470.4±34.3 °C

Use of AG-120

Ivosidenib (AG-120) is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor with an IC50 of 12 nM for mouse IDH1R132H.

Name	Ivosidenib
Synonym	More Synonyms

Description	Ivosidenib (AG-120) is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor with an IC50 of 12 nM for mouse IDH1R132H.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH) Research Areas >> Metabolic Disease
Target	12 nM (mouse IDH1R132H)[1]
References	[1]. Agresta Samuel V, et al. (S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide as therapeutically active compound for treating cancer characterized by a mutant allele of IDH1. From PCT Int. Appl. (2015), WO 2015127172 A1 20150827. [2]. Gu Chong-Hui, et al. Pharmaceutical compositions of therapeutically active compounds comprising (S)-N-((S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide for treating hematologic malignancies with mutant allele of IDH1. From PCT Int. Appl. (2015), WO 2015138839 A1 20150917.

Density	1.5±0.1 g/cm3
Boiling Point	854.3±65.0 °C at 760 mmHg
Molecular Formula	C₂₈H₂₂ClF₃N₆O₃
Molecular Weight	582.961
Flash Point	470.4±34.3 °C
Exact Mass	582.139404
LogP	0.38
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.651
Storage condition	-20℃

AG-120

2-Pyrrolidinecarboxamide, N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-, (2S)-

ivosidenib

N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-L-prolinamide

UNII:Q2PCN8MAM6

(2S)-1-(4-Cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)glycinamide

DC Chemicals Limited
China
Product Name: AG-120 (Ivosidenib)
Price: $400.0/100mg $700.0/250mg $1200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Ivosidenib
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $123/10mM*1mLinDMSO

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AG-120

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