NMS-859

Modify Date: 2024-01-02 09:41:35

NMS-859 Structure
NMS-859 structure
Common Name NMS-859
CAS Number 1449236-96-7 Molecular Weight 349.789
Density 1.5±0.1 g/cm3 Boiling Point 540.7±56.0 °C at 760 mmHg
Molecular Formula C15H12ClN3O3S Melting Point N/A
MSDS N/A Flash Point 280.8±31.8 °C

 Use of NMS-859


NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

 Names

Name NMS-859
Synonym More Synonyms

 NMS-859 Biological Activity

Description NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
Related Catalog
Target

IC50: 360 nM (Cellular p97, 1 mM ATP), 370 nM (Cellular p97, 60 μM ATP)[1]

In Vitro NMS-859 is a potent VCP inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. NMS-859 shows very weak inhibitory activity against VCPC522T. NMS-859 also suppresses the proliferation of cells, with IC50s of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively[1].
Cell Assay Cells are seeded at 1,600 cells per well in 384-well white clear-bottom plates. Twenty-four hours after seeding, cells are treated with NMS-859 (eight dilution points, in duplicate) and incubated for an additional 72 h at 37°C under a 5% CO2 atmosphere. Cells are then lysed, and the ATP content in each well is determined using a thermostable firefly luciferase-based assay as a measure of cell viability. IC50 values are calculated using the percentage of growth of treated cells versus the untreated control[1].
References

[1]. Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9(9):548-56.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 540.7±56.0 °C at 760 mmHg
Molecular Formula C15H12ClN3O3S
Molecular Weight 349.789
Flash Point 280.8±31.8 °C
LogP 2.08
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.673
Storage condition 2-8℃

 Synonyms

3-[(1,1-Dioxido-1,2-benzothiazol-3-yl)amino]phenyl chloroacetate
MFCD05030984
Acetic acid, 2-chloro-, 3-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]phenyl ester
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