NMS-P645
Modify Date: 2024-09-17 12:12:23
NMS-P645 structure
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Common Name | NMS-P645 | ||
|---|---|---|---|---|
| CAS Number | 1482518-95-5 | Molecular Weight | 512.095 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H38ClN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NMS-P645NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively; exhibits excellent selectivity against a large panel of kinases; reverse PIM1-mediated pro-survival signals in prostate cells, such as activation of STAT3 through Tyr705 phosphorylation and resistance to taxane-based treatments; induces a significant anti-proliferative response in PCa cells combined with GDC-0941. |
| Name | NMS-P645 |
|---|
| Description | NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively; exhibits excellent selectivity against a large panel of kinases; reverse PIM1-mediated pro-survival signals in prostate cells, such as activation of STAT3 through Tyr705 phosphorylation and resistance to taxane-based treatments; induces a significant anti-proliferative response in PCa cells combined with GDC-0941. |
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| References | References 1. Casuscelli F, et al. Bioorg Med Chem. 2013 Dec 1;21(23):7364-80. 2. Mologni L, et al. J Cancer. 2017 Jan 1;8(1):140-145. View Related Products by Target Pim |
| Molecular Formula | C28H38ClN5O2 |
|---|---|
| Molecular Weight | 512.095 |