Rosuvastatin calcium
Modify Date: 2024-01-17 04:28:35
Rosuvastatin calcium structure
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Common Name | Rosuvastatin calcium | ||
|---|---|---|---|---|
| CAS Number | 147098-18-8 | Molecular Weight | 503.520 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H27FN3NaO6S | Melting Point | 128-131℃ | |
| MSDS | N/A | Flash Point | N/A | |
Use of Rosuvastatin calciumRosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3]. |
| Name | sodium,7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate |
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| Synonym | More Synonyms |
| Description | Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3]. |
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| Related Catalog | |
| Target |
IC50: 11 nM (HMG-CoA), 195 nM (hERG)[1][2] |
| In Vivo | Rosuvastatin Sodium (10 mg/kg, intraperitoneal) prolonges QTc in conscious and unrestraines guinea pigs from 201±1 to 210±2 ms[2]. Rosuvastatin (20 mg/kg/day, for 2 weeks) significantly reduces very low-density lipoproteins Sodium (VLDL) in diabetes mellitus rats induced by Streptozocin[4]. |
| References |
[4]. Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7. |
| Melting Point | 128-131℃ |
|---|---|
| Molecular Formula | C22H27FN3NaO6S |
| Molecular Weight | 503.520 |
| Exact Mass | 503.150238 |
| PSA | 152.13000 |
| LogP | 2.14780 |
| Hazard Codes | Xi |
|---|
| Sodium (6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate |
| Rosuvastatin Sodium |
| 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, sodium salt, (6E)- (1:1) |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Rosuvastatin calcium
- Price: Click To Check
- Purity: 98.0%
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- China
- Product Name: Rosuvastatin calcium
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
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- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: sodium,7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
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- Contact: Anson
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