Ac-Leu-Val-Lys-aldehyde

Modify Date: 2024-01-05 13:04:14

Ac-Leu-Val-Lys-aldehyde Structure
Ac-Leu-Val-Lys-aldehyde structure
Common Name Ac-Leu-Val-Lys-aldehyde
CAS Number 147600-40-6 Molecular Weight 384.51
Density 1.1±0.1 g/cm3 Boiling Point 665.5±55.0 °C at 760 mmHg
Molecular Formula C19H36N4O4 Melting Point N/A
MSDS N/A Flash Point 356.3±31.5 °C

 Use of Ac-Leu-Val-Lys-aldehyde


Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].

 Names

Name Ac-Leu-Val-Lys-aldehyde
Synonym More Synonyms

 Ac-Leu-Val-Lys-aldehyde Biological Activity

Description Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].
Related Catalog
Target

Cathepsin B:4 nM (IC50)

References

[1]. McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9.  

[2]. Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 665.5±55.0 °C at 760 mmHg
Molecular Formula C19H36N4O4
Molecular Weight 384.51
Flash Point 356.3±31.5 °C
Exact Mass 384.273651
PSA 130.39000
LogP 0.88
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.488

 Synonyms

cathepsin b inhibitor ii
N-Acetyl-L-leucyl-N-[(2S)-6-amino-1-oxo-2-hexanyl]-L-valinamide
L-Valinamide, N-acetyl-L-leucyl-N-[(1S)-5-amino-1-formylpentyl]-
ac-lvk-cho
acetyl-L-leucyl-L-valyl-L-lysinal
ac-leu-val-l-lysinal
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