PKR activator 2

Modify Date: 2024-01-05 12:57:29

PKR activator 2 structure	Common Name	PKR activator 2
	CAS Number	2283422-04-6	Molecular Weight	392.44
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₆N₈OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PKR activator 2

PKR activator 2 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385[1].

Name	PKR activator 2

Description	PKR activator 2 is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385[1].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	Pyruvate kinase-R (PKR)[1]
In Vitro	PKR activator 2 (compound 385) activates wild type PKR, PKR K410E or PKR 510Q with AC50 values <0.3 µΜ[1]. Pyruvate kinase deficiency (PKD) is a disease of red blood cells caused by a deficiency of pyruvate kinase R (PKR) enzyme as a result of autosomal recessive mutations of the PKLR gene. PKR activators can be beneficial to treat disorders and conditions such as but not limited to PKD, thalassemia, hereditary elliptocytosis, anemia (e.g. , congenital anemias (e.g., enzymopathies), hemolytic anemia (e.g. hereditary and/or congenital hemolytic anemia, acquired hemolytic anemia, chronic hemolytic anemia caused by phosphoglycerate kinase deficiency, anemia of chronic diseases, non-spherocytic hemolytic anemia or hereditary spherocytosis)[1].
References	[1]. Giovanni Cianchetta, et al. Pyruvate kinase activators for use in treating blood disorders. WO2019035863A1.

Molecular Formula	C₁₈H₁₆N₈OS
Molecular Weight	392.44