p53 Activator 2

Modify Date: 2024-01-13 17:10:06

p53 Activator 2 structure	Common Name	p53 Activator 2
	CAS Number	2338764-89-7	Molecular Weight	363.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₁N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of p53 Activator 2

p53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC50 of 1.73 µM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models[1].

Name	p53 Activator 2

Description	p53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC50 of 1.73 µM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
References	[1]. Xin-Wei Wei , et al. 2-Styryl-4-aminoquinazoline derivatives as potent DNA-cleavage, p53-activation and in vivo effective anticancer agents. Eur J Med Chem. 2020 Jan 15;186:111851.

Molecular Formula	C₂₀H₂₁N₅O₂
Molecular Weight	363.41

p53 Activator 2

Use of p53 Activator 2

Names

p53 Activator 2 Biological Activity

Chemical & Physical Properties