Win-62005
Modify Date: 2024-01-31 23:03:08
Win-62005 structure
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Common Name | Win-62005 | ||
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| CAS Number | 152633-54-0 | Molecular Weight | 226.23400 | |
| Density | 1.292g/cm3 | Boiling Point | 291.8ºC at 760 mmHg | |
| Molecular Formula | C12H10N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 130.3ºC | |
Use of Win-62005Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively. |
| Name | 5-methyl-6-pyridin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively. |
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| Related Catalog | |
| Target |
Ki: 25 nM (PDE III), 25 nM (PDE III)[1] |
| In Vitro | Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with Ki values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes[1]. |
| In Vivo | After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h[1]. |
| References |
| Density | 1.292g/cm3 |
|---|---|
| Boiling Point | 291.8ºC at 760 mmHg |
| Molecular Formula | C12H10N4O |
| Molecular Weight | 226.23400 |
| Flash Point | 130.3ºC |
| Exact Mass | 226.08500 |
| PSA | 74.69000 |
| LogP | 2.03390 |
| Vapour Pressure | 0.00191mmHg at 25°C |
| Index of Refraction | 1.621 |
| Storage condition | 2-8℃ |
| 2H-Imidazo(4,5-b)pyridin-2-one,1,3-dihydro-5-methyl-6-(4-pyridinyl) |
| 5-Methyl-6-(4-pyridinyl)-2H-imidazo(4,5-b)pyridin-2-one |
| Win-62005 |