GNE-9278
Modify Date: 2025-09-05 17:08:34
GNE-9278 structure
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Common Name | GNE-9278 | ||
|---|---|---|---|---|
| CAS Number | 2315311-83-0 | Molecular Weight | 429.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H27N5O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNE-9278GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD). GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity[1]. |
| Name | GNE-9278 |
|---|
| Description | GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD). GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity[1]. |
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| Related Catalog | |
| Target |
NMDAR[1] |
| In Vitro | GNE-9278 (50 μM) slows deactivation with multiple agonists (D-Glu, L-Glu and L-CCG-IV) and enhances the potency of both Glu and Gly[1]. GNE-9278 robustly potentiates GluN2A, 2B, 2C and 2D-containing NMDARs as measured by calcium influx assays from HEK cell lines with the EC50s of 0.74, 3.07, 0.47, and 0.32 μM, respectively[1]. |
| References |
| Molecular Formula | C21H27N5O3S |
|---|---|
| Molecular Weight | 429.54 |