Tripelennamine (hydrochloride)
Tripelennamine (hydrochloride) structure
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Common Name | Tripelennamine (hydrochloride) | ||
|---|---|---|---|---|
| CAS Number | 154-69-8 | Molecular Weight | 291.81900 | |
| Density | 1.20 | Boiling Point | 387.8ºC at 760 mmHg | |
| Molecular Formula | C16H22ClN3 | Melting Point | 192-193ºC | |
| MSDS | Chinese USA | Flash Point | 188.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Determination of antihistamines based on the formation of mixed aggregates with surfactants.
Analyst 123(5) , 1079-84, (1998) The determination of antihistamines based on the measurement of the critical micelle concentration (c.m.c.) of mixed sodium dodecyl sulfate (SDS)-antihistamine aggregates is proposed. The dye Coomassie Brilliant Blue G (CBBG) was used as a photometric probe f... |
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Role of N-methyl-D-aspartate receptors in gastric mucosal blood flow induced by histamine.
J. Neurosci. Res. 77 , 730-738, (2004) Ionotropic N-methyl-D-aspartate (NMDA) receptor agonists, L-aspartic acid (L-Asp) and NMDA, have been shown to inhibit histamine-stimulated acid secretion, but their effect on gastric mucosal blood flow (GMBF) is largely unknown. The aim of this study was to ... |
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Cationic amphiphilic drugs are potent inhibitors of yeast sporulation.
PLoS ONE 7(8) , e42853, (2012) Meiosis is a highly regulated developmental process that occurs in all eukaryotes that engage in sexual reproduction. Previous epidemiological work shows that male and female infertility is rising and environmental factors, including pollutants such as organi... |
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Involvement of histamine H1 and H2 receptors in the regulation of STAT-1 phosphorylation: inverse agonism exhibited by the receptor antagonists.
Int. Immunopharmacol. 5(7-8) , 1299-309, (2005) Signal transducer and activator of transcription-1 (STAT1) is a latent signal transducer protein which, on phosphorylation, is translocated from the cytoplasm to the nucleus and is subsequently activated. This study was designed to determine the involvement o... |
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Myasthenia gravis-like syndrome in a Hereford heifer.
J. Vet. Intern. Med. 22(1) , 231-3, (2008)
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H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds.
J. Appl. Physiol. 92(4) , 1515-23, (2002) It has been suggested that pulmonary injury and inflammation-induced histamine release from airway mast cells may contribute to exercise-induced arterial hypoxemia (EIAH). Because stress failure of pulmonary capillaries and EIAH are routinely observed in exer... |
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The discriminative stimulus effects of tripelennamine in humans.
Psychopharmacology 126(2) , 140-6, (1996) Twenty volunteers were trained to discriminate between 75 mg tripelennamine (TP) and placebo. During the first four sessions, the drugs were identified prior to ingestion by letter code. During the next six sessions, the procedure was the same except the caps... |