SB 204990
Modify Date: 2025-08-22 21:43:03
SB 204990 structure
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Common Name | SB 204990 | ||
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| CAS Number | 154566-12-8 | Molecular Weight | 389.27000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H22Cl2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SB 204990SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme. |
| Name | 2-((3R,5S)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxy-2-oxotetrahydrofuran-3-yl)acetic acid |
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| Description | SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme. |
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| Related Catalog | |
| Target |
ACLY[1]. |
| In Vitro | SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels[1]. |
| In Vivo | SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels[2]. |
| References |
| Molecular Formula | C18H22Cl2O5 |
|---|---|
| Molecular Weight | 389.27000 |
| Exact Mass | 388.08400 |
| PSA | 83.83000 |
| LogP | 4.00770 |
| Storage condition | 2-8℃ |