PEG5-Tos

Modify Date: 2024-01-16 19:14:42

PEG5-Tos Structure
PEG5-Tos structure
Common Name PEG5-Tos
CAS Number 155130-15-7 Molecular Weight 392.464
Density 1.2±0.1 g/cm3 Boiling Point 524.4±50.0 °C at 760 mmHg
Molecular Formula C17H28O8S Melting Point N/A
MSDS N/A Flash Point 270.9±30.1 °C

 Use of PEG5-Tos


PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 14-Hydroxy-3,6,9,12-tetraoxatetradec-1-yl 4-methylbenzenesulfonate
Synonym More Synonyms

 PEG5-Tos Biological Activity

Description PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 524.4±50.0 °C at 760 mmHg
Molecular Formula C17H28O8S
Molecular Weight 392.464
Flash Point 270.9±30.1 °C
Exact Mass 392.150482
LogP -0.48
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.506

 Synonyms

3,6,9,12-Tetraoxatetradecane-1,14-diol, mono(4-methylbenzenesulfonate)
14-Hydroxy-3,6,9,12-tetraoxatetradec-1-yl 4-methylbenzenesulfonate