m-PEG5-Tos

Modify Date: 2026-07-01 12:40:30

m-PEG5-Tos Structure
m-PEG5-Tos structure
Common Name m-PEG5-Tos
CAS Number 80755-67-5 Molecular Weight 424.50600
Density N/A Boiling Point N/A
Molecular Formula C18H30O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of m-PEG5-Tos


m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].

 Names

Name 2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol,4-methylbenzenesulfonic acid
Synonym More Synonyms

 m-PEG5-Tos Biological Activity

Description m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277)[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Yuxia Zhao, et al. Derivative of silybin ethers, and synthetic method and application thereof. Patent CN105037337A.

 Chemical & Physical Properties

Molecular Formula C18H30O8S
Molecular Weight 424.50600
Exact Mass 424.17700
PSA 129.13000
LogP 2.01400
InChIKey ARGVXLRPEZMWEQ-UHFFFAOYSA-N
SMILES COCCOCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1
Storage condition 2-8°C

 Synthetic Route

~99%

m-PEG5-Tos Structure

m-PEG5-Tos

CAS#:80755-67-5

Learn More
Literature: Wolfe, Amanda L.; Duncan, Katharine K.; Lajiness, James P.; Zhu, Kaicheng; Duerfeldt, Adam S.; Boger, Dale L. Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6845 - 6857

~%

m-PEG5-Tos Structure

m-PEG5-Tos

CAS#:80755-67-5

Learn More
Literature: Ajayaghosh, Ayyappanpillai; Arunkumar, Easwaran Organic Letters, 2005 , vol. 7, # 15 p. 3135 - 3138

~%

m-PEG5-Tos Structure

m-PEG5-Tos

CAS#:80755-67-5

Learn More
Literature: Kocian, Oldrich; Chiu, Kwok W.; Demeure, Roger; Gallez, Bernard; Jones, Christopher J.; Thornback, John R. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 5 p. 527 - 536

~%

m-PEG5-Tos Structure

m-PEG5-Tos

CAS#:80755-67-5

Learn More
Literature: Kocian, Oldrich; Chiu, Kwok W.; Demeure, Roger; Gallez, Bernard; Jones, Christopher J.; Thornback, John R. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 5 p. 527 - 536

~%

m-PEG5-Tos Structure

m-PEG5-Tos

CAS#:80755-67-5

Learn More
Literature: Selve, Claude; Achilefu, Samuel Journal of the Chemical Society, Chemical Communications, 1990 , # 13 p. 911 - 912

~%

m-PEG5-Tos Structure

m-PEG5-Tos

CAS#:80755-67-5

Learn More
Literature: Selve, Claude; Achilefu, Samuel Journal of the Chemical Society, Chemical Communications, 1990 , # 13 p. 911 - 912

 Synonyms

2,5,8,11,14-Pentaoxahexadecan-16-ol,4-methylbenzenesulfonate
pentaethylene glycol mono methyl ether tosylate
pentaethyleneglycol monomethyl ether monotosylate
pentaethyleneglycol momomethyl ether tosylate
14-methoxy-3,6,9,12-tetraoxatetradecyl toluene-p-sulfonate
TsO(CH2CH2O)5Me
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.