Alniditan dihydrochloride

Modify Date: 2024-01-13 18:59:00

Alniditan dihydrochloride Structure
Alniditan dihydrochloride structure
Common Name Alniditan dihydrochloride
CAS Number 155428-00-5 Molecular Weight 375.34
Density N/A Boiling Point N/A
Molecular Formula C17H28Cl2N4O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Alniditan dihydrochloride


Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK 293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects[1][2].

 Names

Name Alniditan dihydrochloride

 Alniditan dihydrochloride Biological Activity

Description Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK 293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects[1][2].
Related Catalog
Target

human 5-HT1B Receptor:1.7 nM (IC50)

human 5-HT1D Receptor:1.3 nM (IC50)

5-HT1B Receptor:0.9 nM (Kd)

5-HT1D Receptor:1.2 nM (Kd)

In Vitro In vitro, Alniditan exhibits little vasoconstrictive effects on the rat basilar artery, although at a very high concentration 1 mM, Alniditan causes intensive constriction, most likely through a mechanism independent from 5-HT receptor activation[1].
In Vivo The intraperitoneal administration of Alniditan ED50=9 μg/kg dose dependly reduces [125I]-BSA extravasation in the rat meninges when done 30 min before stimulation. Alniditan dose dependently attenuateds the neurogenic inflammation in vivo model of neurogenic inflammation[1].
References

[1]. Limmroth V, et al. Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery. Eur J Pharmacol. 1999 Oct 8;382(2):103-9.

[2]. Lesage AS, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65.

 Chemical & Physical Properties

Molecular Formula C17H28Cl2N4O
Molecular Weight 375.34
Top Suppliers:I want be here


Get all suppliers and price by the below link:

Alniditan dihydrochloride suppliers


Price: ¥3850/10 mM * 1 mL in DMSO

Reference only. check more Alniditan dihydrochloride price