RIP2 kinase inhibitor 2
Modify Date: 2024-01-03 00:55:16
RIP2 kinase inhibitor 2 structure
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Common Name | RIP2 kinase inhibitor 2 | ||
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| CAS Number | 1581270-11-2 | Molecular Weight | 432.536 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 670.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C21H28N4O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 359.0±31.5 °C | |
Use of RIP2 kinase inhibitor 2RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9. |
| Name | RIP2 kinase inhibitor 2 |
|---|---|
| Synonym | More Synonyms |
| Description | RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9. |
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| Related Catalog | |
| Target |
RIP2 Kinase[1] |
| In Vitro | RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation[1]. |
| Animal Admin | Rats[1] Rats are orally pre-dosed with the RIP2 kinase inhibitor 2, at doses of 0.016, 0.16 and 1.6 mg/kg (n=8 rats/group), followed by dosing with L18-MDP (50 μg/rat) 0.25 hours after pre-dosing with the compound. The IL8 cytokine levels and percentage levels are calculated as the mean±standard error of the mean (n=8 rats/group). |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 670.0±55.0 °C at 760 mmHg |
| Molecular Formula | C21H28N4O4S |
| Molecular Weight | 432.536 |
| Flash Point | 359.0±31.5 °C |
| Exact Mass | 432.183136 |
| LogP | 3.27 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.595 |
| Storage condition | 2-8℃ |
| 4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)- |
| N-(4,5-Dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)-6-[(2-methyl-2-propanyl)sulfonyl]-4-quinolinamine |