Amotosalen hydrochloride

Modify Date: 2024-01-02 19:22:08

Amotosalen hydrochloride Structure
Amotosalen hydrochloride structure
Common Name Amotosalen hydrochloride
CAS Number 161262-45-9 Molecular Weight 337.79800
Density N/A Boiling Point 488.8ºC at 760mmHg
Molecular Formula C17H21Cl2NO4 Melting Point N/A
MSDS N/A Flash Point 249.4ºC

 Use of Amotosalen hydrochloride


Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens[1].

 Names

Name 3-(2-aminoethoxymethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one,hydrochloride
Synonym More Synonyms

 Amotosalen hydrochloride Biological Activity

Description Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens[1].
Related Catalog
In Vitro When activated by light, Amotosalen binds to the nucleic acid of the pathogen and prevents replication. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells[1].
References

[1]. Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59. BioDrugs. 2003;17(1):66-8.

 Chemical & Physical Properties

Boiling Point 488.8ºC at 760mmHg
Molecular Formula C17H21Cl2NO4
Molecular Weight 337.79800
Flash Point 249.4ºC
Exact Mass 337.10800
PSA 78.60000
LogP 4.44200
Vapour Pressure 1.06E-09mmHg at 25°C

 Synthetic Route

~%

Amotosalen hydrochloride Structure

Amotosalen hydr...

CAS#:161262-45-9

Literature: Cerus Corporation Patent: US6544727 B1, 2003 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

Amotosalen hydrochloride (USAN)
Amotosalen HCl
S-59
7H-Furo(3,2-g)(1)benzopyran-7-one,3-((2-aminoethoxy)methyl)-2,5,9-trimethyl-,hydrochloride
Amotosalen hydrochloride
4'(4-amino-2-oxa)butyl-4,5',8-trimethylpsoralen Hydrochloride