Trioxsalen

Modify Date: 2024-01-08 22:50:35

Trioxsalen structure	Common Name	Trioxsalen
	CAS Number	3902-71-4	Molecular Weight	228.243
	Density	1.2±0.1 g/cm3	Boiling Point	389.0±30.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₂O₃	Melting Point	229-231ºC(lit.)
	MSDS	Chinese USA	Flash Point	189.1±24.6 °C
	Symbol	GHS05, GHS08	Signal Word	Danger

Use of Trioxsalen

Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Name	trioxsalen
Synonym	More Synonyms

Description	Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology

Density	1.2±0.1 g/cm3
Boiling Point	389.0±30.0 °C at 760 mmHg
Melting Point	229-231ºC(lit.)
Molecular Formula	C₁₄H₁₂O₃
Molecular Weight	228.243
Flash Point	189.1±24.6 °C
Exact Mass	228.078644
PSA	43.35000
LogP	3.80
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.613
Storage condition	2-8°C
Water Solubility	DMSO: soluble

Trioxsalen MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1576000

CHEMICAL NAME :: 7H-Furo(3,2-g)(1)benzopyran-7-one, 2,5,9-trimethyl-

CAS REGISTRY NUMBER :: 3902-71-4

BEILSTEIN REFERENCE NO. :: 0221723

LAST UPDATED :: 199806

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C14-H12-O3

MOLECULAR WEIGHT :: 228.26

WISWESSER LINE NOTATION :: T C566 DO LVOJ B1 E1 J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >22 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 3 mg/L

REFERENCE :: BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962- Volume(issue)/page/year: 20,1431,1981 *** REVIEWS *** IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,357,1986 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,357,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,366,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5360 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)

Symbol	GHS05, GHS08
Signal Word	Danger
Hazard Statements	H314-H351
Precautionary Statements	P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C: Corrosive;
Risk Phrases	R34;R40
Safety Phrases	26-36/37/39-45
RIDADR	UN 1759 8
WGK Germany	2
RTECS	LV1576000
HS Code	2932999099

Precursor 5
CAS#:72478-66-1 4,8-dimethyl-7-... CAS#:4115-76-8 4,8-Dimethyl-7-... CAS#:69897-63-8 7-(2-chloroprop... CAS#:3993-43-9 2H-1-Benzopyran...
CAS#:3993-44-0 4,8-dimethyl-6-...
DownStream 8
CAS#:2462-84-2 methyl 9-octade... CAS#:161262-45-9 Amotosalen hydr... CAS#:21902-10-3 2,5,9-trimethyl... CAS#:62442-57-3 7H-Furo[3,2-g][...
CAS#:62442-58-4 1H-Isoindole-1,... CAS#:62442-59-5 hmt CAS#:62442-60-8 7H-Furo[3, 2-g]... CAS#:64358-50-5 3H-Amt

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Mitotic cohesin subunit Mcd1 regulates the progression of meiotic recombination in budding yeast.

J. Microbiol. Biotechnol. 25 , 598-605, (2015)

The cohesin complex holds sister chromatids together and prevents premature chromosome segregation until the onset of anaphase. Mcd1 (also known as Scc1), the α-kleisin subunit of cohesin, is a key re...

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.

J. Cell Biol. 208(5) , 563-79, (2015)

Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in human cells in response to a panel of suble...

Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation.

Bioconjug. Chem. 18(2) , 431-7, (2007)

DNA interstrand cross-links are formed by chemotherapy drugs as well as by products of normal oxidative metabolism. Despite their importance, the pathways of cross-link metabolism are poorly understoo...

EINECS 223-459-0

4,2',8-trimethylpsoralen

4,5',8-Trimethylpsoralen

2,5,9-Trimethyl-7H-furo[3,2-g]chromen-7-one

Trisoralen

7H-Furo(3,2-g)(1)benzopyran-7-one, 2,5,9-trimethyl-

6-Hydroxy-β,2,7-trimethyl-5-benzofuranacrylic Acid δ-Lactone

2,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-one

2,5,9-trimethylfuro[3,2-g]chromen-7-one

Trioxysalenum

Trioxysalene

UNII-Y6UY8OV51T

Trioxisaleno

7H-Furo[3,2-g][1]benzopyran-7-one, 2,5,9-trimethyl-

trioxysalen

MFCD00005010

Elder 8011

4,5′,8-Trimethylpsoralen

Trioxsalen

4,5‘,8-Trimethylpsoralen

2,5,9-Trimethylfuro[3,2-g]benzopyran-7-one

Trimethylpsoralen

DC Chemicals Limited
China
Product Name: NSC71047
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: $66/10mM*1mLinDMSO

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Trioxsalen

Use of Trioxsalen

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Trioxsalen Biological Activity

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MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

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