Trioxsalen

Modify Date: 2026-07-08 22:38:36

Trioxsalen structure	Common Name	Trioxsalen
	CAS Number	3902-71-4	Molecular Weight	228.243
	Density	1.2±0.1 g/cm3	Boiling Point	389.0±30.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₂O₃	Melting Point	229-231ºC(lit.)
	MSDS	Chinese USA	Flash Point	189.1±24.6 °C
	Symbol	GHS05, GHS08	Signal Word	Danger

Use of Trioxsalen

Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Summary: trioxsalen (triosalen), CAS号3902-71-4, molecular formula C14H12O3, molecular weight 228.243, crystalline powder. Melting point 229-231°C, boiling point 389.0±30.0 °C, density 1.2±0.1 g/cm3. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	trioxsalen
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.2±0.1 g/cm3
Boiling Point	389.0±30.0 °C at 760 mmHg
Melting Point	229-231ºC(lit.)
Molecular Formula	C₁₄H₁₂O₃
Molecular Weight	228.243
Flash Point	189.1±24.6 °C
Exact Mass	228.078644
PSA	43.35000
LogP	3.80
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.613
InChIKey	FMHHVULEAZTJMA-UHFFFAOYSA-N
SMILES	Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1
Storage condition	2-8°C
Water Solubility	DMSO: soluble

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Trioxsalen MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1576000

CHEMICAL NAME :: 7H-Furo(3,2-g)(1)benzopyran-7-one, 2,5,9-trimethyl-

CAS REGISTRY NUMBER :: 3902-71-4

BEILSTEIN REFERENCE NO. :: 0221723

LAST UPDATED :: 199806

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C14-H12-O3

MOLECULAR WEIGHT :: 228.26

WISWESSER LINE NOTATION :: T C566 DO LVOJ B1 E1 J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >22 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 3 mg/L

REFERENCE :: BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962- Volume(issue)/page/year: 20,1431,1981 *** REVIEWS *** IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,357,1986 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,357,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,366,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5360 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS05, GHS08
Signal Word	Danger
Hazard Statements	H314-H351
Precautionary Statements	P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C: Corrosive;
Risk Phrases	R34;R40
Safety Phrases	26-36/37/39-45
RIDADR	UN 1759 8
WGK Germany	2
RTECS	LV1576000
HS Code	2932999099

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 5
CAS#:72478-66-1 4,8-dimethyl-7-... CAS#:4115-76-8 4,8-Dimethyl-7-... CAS#:69897-63-8 7-(2-chloroprop... CAS#:3993-43-9 2H-1-Benzopyran...
CAS#:3993-44-0 4,8-dimethyl-6-...
DownStream 8
CAS#:2462-84-2 methyl 9-octade... CAS#:161262-45-9 Amotosalen hydr... CAS#:21902-10-3 2,5,9-trimethyl... CAS#:62442-57-3 7H-Furo[3,2-g][...
CAS#:62442-58-4 1H-Isoindole-1,... CAS#:62442-59-5 hmt CAS#:62442-60-8 7H-Furo[3, 2-g]... CAS#:64358-50-5 3H-Amt

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Mitotic cohesin subunit Mcd1 regulates the progression of meiotic recombination in budding yeast.

J. Microbiol. Biotechnol. 25 , 598-605, (2015)

The cohesin complex holds sister chromatids together and prevents premature chromosome segregation until the onset of anaphase. Mcd1 (also known as Scc1), the α-kleisin subunit of cohesin, is a key re...

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.

J. Cell Biol. 208(5) , 563-79, (2015)

Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in human cells in response to a panel of suble...

Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation.

Bioconjug. Chem. 18(2) , 431-7, (2007)

DNA interstrand cross-links are formed by chemotherapy drugs as well as by products of normal oxidative metabolism. Despite their importance, the pathways of cross-link metabolism are poorly understoo...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_OPM1-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-OC1MY5-m4-1

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-KMS_34-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_L363-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_OCIMY7-m4-1

Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-MM1R-m4-1

Total 693, Current Page 1 of 70

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

EINECS 223-459-0

4,2',8-trimethylpsoralen

4,5',8-Trimethylpsoralen

2,5,9-Trimethyl-7H-furo[3,2-g]chromen-7-one

Trisoralen

6-Hydroxy-β,2,7-trimethyl-5-benzofuranacrylic Acid δ-Lactone

2,5,9-Trimethyl-7H-furo[3,2-g][1]benzopyran-7-one

2,5,9-trimethylfuro[3,2-g]chromen-7-one

Trioxysalenum

Trioxysalene

UNII-Y6UY8OV51T

Trioxisaleno

trioxysalen

MFCD00005010

Elder 8011

4,5′,8-Trimethylpsoralen

Trioxsalen

4,5‘,8-Trimethylpsoralen

2,5,9-Trimethylfuro[3,2-g]benzopyran-7-one

Trimethylpsoralen

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the safety information for trioxsalen?

A: Safety information for trioxsalen: 26-36/37/39-45.

Q: What is the melting point of trioxsalen?

A: Melting point of trioxsalen is 229-231ºC(lit.).

Q: What is the polar surface area (PSA) of trioxsalen?

A: Polar surface area (PSA) of trioxsalen is 43.35000.

Q: What is the SMILES notation of trioxsalen?

A: SMILES notation of trioxsalen is Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1.

Q: What is the LogP of trioxsalen?

A: LogP of trioxsalen is 3.80.

Q: What is the InChIKey of trioxsalen?

A: InChIKey of trioxsalen is FMHHVULEAZTJMA-UHFFFAOYSA-N.

Q: What is the molecular weight of trioxsalen?

A: Molecular weight of trioxsalen is 228.243.

Q: What are the storage conditions for trioxsalen?

A: Storage conditions for trioxsalen: 2-8°C.

Q: What are the upstream materials of trioxsalen?

A: Related upstream materials(CAS) of trioxsalen: 72478-66-1;4115-76-8;69897-63-8;3993-43-9;3993-44-0.

Q: What is the CAS number of trioxsalen?

A: CAS number of trioxsalen is 3902-71-4.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

BioBioPha

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Trioxsalen
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Trioxsalen
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Get all suppliers and price by the below link:

Trioxsalen suppliers

Price: $66/10mM*1mLinDMSO

Reference only. check more Trioxsalen price

Trioxsalen

Use of Trioxsalen

Names

Trioxsalen Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Precursor & DownStream

Customs

Articles32

TrioxsalenBioassay

Synonyms

Trioxsalen | FAQ

Trioxsalenfactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.