RWJ-445167

Modify Date: 2024-01-10 12:08:46

RWJ-445167 Structure
RWJ-445167 structure
Common Name RWJ-445167
CAS Number 226566-43-4 Molecular Weight 436.485
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C18H24N6O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RWJ-445167


RWJ-445167 is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

 Names

Name RWJ-445167
Synonym More Synonyms

 RWJ-445167 Biological Activity

Description RWJ-445167 is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.
Related Catalog
Target

Ki: 4.0 nM (thrombin), 230 nM (factor Xa)[1]

References

[1]. RWJ-445167, et al. Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa. Chem Biol Drug Des. 2006 Jul;68(1):29-36.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C18H24N6O5S
Molecular Weight 436.485
Exact Mass 436.152893
LogP -0.17
Index of Refraction 1.644
Storage condition 2-8℃

 Synonyms

N-[2-(Carbamimidamidooxy)ethyl]-2-[6-methyl-3-{[(3-methylphenyl)sulfonyl]amino}-2-oxo-1(2H)-pyridinyl]acetamide
1(2H)-Pyridineacetamide, N-[2-[[(aminoiminomethyl)amino]oxy]ethyl]-6-methyl-3-[[(3-methylphenyl)sulfonyl]amino]-2-oxo-
N-[2-(carbamimidamidooxy)ethyl]-2-[6-methyl-3-{[(3-methylphenyl)sulfonyl]amino}-2-oxopyridin-1(2H)-yl]acetamide