Bromo-PEG8-Boc

Modify Date: 2024-01-09 17:05:52

Bromo-PEG8-Boc Structure
Bromo-PEG8-Boc structure
Common Name Bromo-PEG8-Boc
CAS Number 1623792-00-6 Molecular Weight 561.501
Density 1.2±0.1 g/cm3 Boiling Point 557.0±45.0 °C at 760 mmHg
Molecular Formula C23H45BrO10 Melting Point N/A
MSDS N/A Flash Point 290.6±28.7 °C

 Use of Bromo-PEG8-Boc


Bromo-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bromo-PEG8-t-butyl ester
Synonym More Synonyms

 Bromo-PEG8-Boc Biological Activity

Description Bromo-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 557.0±45.0 °C at 760 mmHg
Molecular Formula C23H45BrO10
Molecular Weight 561.501
Flash Point 290.6±28.7 °C
Exact Mass 560.219604
LogP -0.11
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.467

 Synonyms

3,6,9,12,15,18,21,24-Octaoxaheptacosan-27-oic acid, 1-bromo-, 1,1-dimethylethyl ester
MFCD26793748
2-Methyl-2-propanyl 1-bromo-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate
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