4-hydroxy Atorvastatin lactone

Modify Date: 2024-01-04 07:15:16

4-hydroxy Atorvastatin lactone Structure
4-hydroxy Atorvastatin lactone structure
Common Name 4-hydroxy Atorvastatin lactone
CAS Number 163217-70-7 Molecular Weight 556.62
Density N/A Boiling Point N/A
Molecular Formula C33H33FN2O5 Melting Point 103-106℃
MSDS N/A Flash Point N/A

 Use of 4-hydroxy Atorvastatin lactone


4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1].

 Names

Name 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(4-hydroxyphenyl)-4-phenyl-2-propan-2-ylpyrrole-3-carboxamide
Synonym More Synonyms

 4-hydroxy Atorvastatin lactone Biological Activity

Description 4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1].
Related Catalog
References

[1]. Jemal M, et al. Quantitation of the acid and lactone forms of atorvastatin and its biotransformation products in human serum by high-performance liquid chromatography with electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 1999;13(11):1003-15.

 Chemical & Physical Properties

Melting Point 103-106℃
Molecular Formula C33H33FN2O5
Molecular Weight 556.62
Exact Mass 556.23700
PSA 100.79000
LogP 6.57210

 Synonyms

5-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
4-Hydroxy Atorvastatin Lactone
UNII-1316I46GEX