GDC-0927

Modify Date: 2024-01-14 18:47:39

GDC-0927 Structure
GDC-0927 structure
Common Name GDC-0927
CAS Number 1642297-01-5 Molecular Weight 461.52
Density N/A Boiling Point N/A
Molecular Formula C28H28FNO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GDC-0927


GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist.

 Names

Name GDC-0927

 GDC-0927 Biological Activity

Description GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist.
Related Catalog
Target

Estrogen receptor[1]

In Vivo GDC-0927 is a novel, potent, non-steroidal, orally bioavailable, selective ER antagonist/ER degrader (SERD) that induces tumor regression in estrogen receptor (ER)+breast cancer (BC) patient-derived xenograft models[1].
References

[1]. MN Dickler, et al. Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive (ER+) HER2-negative metastatic breast cancer (BC). AACR; Cancer Res 2018;78(4 Suppl):Abstract nr PD5-10.

 Chemical & Physical Properties

Molecular Formula C28H28FNO4
Molecular Weight 461.52
Storage condition 2-8℃
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