Fumarate hydratase-IN-1
Modify Date: 2024-01-02 17:59:45
Fumarate hydratase-IN-1 structure
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Common Name | Fumarate hydratase-IN-1 | ||
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| CAS Number | 1644060-37-6 | Molecular Weight | 446.538 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 693.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C27H30N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 372.9±31.5 °C | |
Use of Fumarate hydratase-IN-1Fumarate hydratase-IN-1, an enzyme of the TCA cycle. Inhibition of fumarate hydratase-IN-1 can contribute to tumorigenicity in some cells. The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target.[1]In vitro: The activity of this enzyme was measured using a well-established assay that monitored the conversion of fumarate into L-malate and subsequent oxidation of L-malate to oxaloacetate by malate dehydrogenase. Initial controls established that neither the carboxylic acid 3 nor ester 2 inhibited malate dehydrogenase Using this two-enzyme protocol we found that carboxylic acid 3 inhibited fumarate hydratase in a dose-dependent fashion in vitro. Besides, inhibition of fumarate hydratase can contribute to tumorigenicity in some cells.[1] |
| Name | Fumarate hydratase-IN-1 |
|---|---|
| Synonym | More Synonyms |
| Description | Fumarate hydratase-IN-1, an enzyme of the TCA cycle. Inhibition of fumarate hydratase-IN-1 can contribute to tumorigenicity in some cells. The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target.[1]In vitro: The activity of this enzyme was measured using a well-established assay that monitored the conversion of fumarate into L-malate and subsequent oxidation of L-malate to oxaloacetate by malate dehydrogenase. Initial controls established that neither the carboxylic acid 3 nor ester 2 inhibited malate dehydrogenase Using this two-enzyme protocol we found that carboxylic acid 3 inhibited fumarate hydratase in a dose-dependent fashion in vitro. Besides, inhibition of fumarate hydratase can contribute to tumorigenicity in some cells.[1] |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 693.0±55.0 °C at 760 mmHg |
| Molecular Formula | C27H30N2O4 |
| Molecular Weight | 446.538 |
| Flash Point | 372.9±31.5 °C |
| Exact Mass | 446.220551 |
| LogP | 4.77 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.616 |
| Storage condition | 2-8℃ |
| Ethyl (3S,3aR)-1-(4-biphenylylmethyl)-3-[2-(methylamino)-2-oxoethyl]-2-oxo-1,2,3,4,5,6-hexahydro-3aH-indole-3a-carboxylate |
| 3aH-Indole-3a-carboxylic acid, 1-([1,1'-biphenyl]-4-ylmethyl)-1,2,3,4,5,6-hexahydro-3-[2-(methylamino)-2-oxoethyl]-2-oxo-, ethyl ester, (3S,3aR)- |