Combretastatin A4 disodium phosphate
Modify Date: 2024-01-08 16:41:27
Combretastatin A4 disodium phosphate structure
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Common Name | Combretastatin A4 disodium phosphate | ||
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| CAS Number | 168555-66-6 | Molecular Weight | 440.292 | |
| Density | N/A | Boiling Point | 611.8ºC at 760 mmHg | |
| Molecular Formula | C18H19Na2O8P | Melting Point | 238-242ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Combretastatin A4 disodium phosphateFosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.IC50 Value: 4 nM [1]Target: microtubulein vitro: Cytotoxic IC(50) values of CA-4 in human bladder cancer cells were below 4 nM. Analyses of cell-cycle distribution showed CA-4 obviously induced G(2)-M phase arrest with sub-G(1) formation. The analyses of apoptosis showed that CA-4 induced caspase-3 activation and decreased BubR1 and Bub3 in cancer cells [1]. The enhanced apoptosis induced by dasatinib plus CA-4 was accompanied by a greater extent of mitochondrial depolarization, caspase-3 activation and PARP cleavage in HO-8910 cells. Furthermore, elevated expression of Mcl-1 led to a reduced apoptosis induced by dasatinib plus CA-4, highlighting that downregulated Mcl-1 was necessary for the potentiating effect of dasatinib to CA-4-triggered apoptosis [2].in vivo: The increased anticancer efficacy of dasatinib combined with CA-4 was further validated in a human HO-8910 ovarian cancer xenograft model in nude mice [2]. There was a significant, concentration dependent increase in mean arterial blood pressure with a maximum increase of about 60% of the baseline MAP at 30 mg/kg of CA4P compared to the saline control. However, there was no significant increase in the cardiac troponin I level after CA4P injection [3].Clinical trial: A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome [4]. |
| Name | disodium,[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate |
|---|---|
| Synonym | More Synonyms |
| Description | Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.IC50 Value: 4 nM [1]Target: microtubulein vitro: Cytotoxic IC(50) values of CA-4 in human bladder cancer cells were below 4 nM. Analyses of cell-cycle distribution showed CA-4 obviously induced G(2)-M phase arrest with sub-G(1) formation. The analyses of apoptosis showed that CA-4 induced caspase-3 activation and decreased BubR1 and Bub3 in cancer cells [1]. The enhanced apoptosis induced by dasatinib plus CA-4 was accompanied by a greater extent of mitochondrial depolarization, caspase-3 activation and PARP cleavage in HO-8910 cells. Furthermore, elevated expression of Mcl-1 led to a reduced apoptosis induced by dasatinib plus CA-4, highlighting that downregulated Mcl-1 was necessary for the potentiating effect of dasatinib to CA-4-triggered apoptosis [2].in vivo: The increased anticancer efficacy of dasatinib combined with CA-4 was further validated in a human HO-8910 ovarian cancer xenograft model in nude mice [2]. There was a significant, concentration dependent increase in mean arterial blood pressure with a maximum increase of about 60% of the baseline MAP at 30 mg/kg of CA4P compared to the saline control. However, there was no significant increase in the cardiac troponin I level after CA4P injection [3].Clinical trial: A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome [4]. |
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| Related Catalog | |
| References |
| Boiling Point | 611.8ºC at 760 mmHg |
|---|---|
| Melting Point | 238-242ºC |
| Molecular Formula | C18H19Na2O8P |
| Molecular Weight | 440.292 |
| Exact Mass | 440.061279 |
| PSA | 119.15000 |
| LogP | 4.23930 |
| Vapour Pressure | 7.99E-16mmHg at 25°C |
| Storage condition | Refrigerator |
| Water Solubility | H2O: soluble5mg/mL, clear |
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| Fosbretabulin disodium |
| Phenol, 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, dihydrogen phosphate, sodium salt (1:2) |
| Fosbretabulin disodium (USAN) |
| Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium |
| Combretastatin A-4 phosphate |
| Zybrestat |
| Disodium 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]phenyl phosphate |
| CA4DP |
| Combretastatin A4 disodium phosphate |
| Fosbretabulin (disodium) |
| CoMbretastatin A4 Phosphate DisodiuM Salt |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Combretastatin A4 disodium phosphate
- Price: ￥888.0/20mg ￥748.0/10mg ￥2308.0/50mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Fosbretabulin disodium
- Price: $300.0/100mg $550.0/250mg $1300.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
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Price: $127/10mM*1mLinWater
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