康普瑞汀磷酸二钠

• 常用名: 康普瑞汀磷酸二钠
• 英文名: Combretastatin A4 disodium phosphate
• CAS号: 168555-66-6
• 分子量: 440.292
• 密度: N/A
• 沸点: 611.8ºC at 760 mmHg
• 分子式: C₁₈H₁₉Na₂O₈P
• 熔点: 238-242ºC
• 闪点: N/A

康普瑞汀磷酸二钠用途

Fosbretabulin(CA 4DP; CA 4P)二钠是微管去稳定剂,能靶向损伤血管。

康普瑞汀磷酸二钠名称

• 中文名: 考布他丁 A-4 磷酸二钠盐
• 英文名: disodium,[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate
• 中文别名: 康布瑞汀磷酸二钠 | 康普瑞汀磷酸二钠

康普瑞汀磷酸二钠生物活性

• 描述: Fosbretabulin(CA 4DP; CA 4P)二钠是微管去稳定剂,能靶向损伤血管。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Shen CH, Shee JJ, Wu JY, Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model. Br J Pharmacol. 2010 Aug;160(8):2008-27.

  [2]. Zhang C, Zhou SS, Li XR, Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo. Oncol Rep. 2013 Jun;29(6):2275-82.

  [3]. Ke Q, Bodyak N, Rigor DL, Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats. Vascul Pharmacol. 2009 Nov-Dec;51(5-6):337-43.

  [4]. Mooney CJ, Nagaiah G, Fu P, A phase II trial of fosbretabulin in advanced anaplastic thyroid carcinoma and correlation of baseline serum-soluble intracellular adhesion molecule-1 with outcome. Thyroid. 2009 Mar;19(3):233-40.

康普瑞汀磷酸二钠物理化学性质

• 沸点: 611.8ºC at 760 mmHg
• 熔点: 238-242ºC
• 分子式: C₁₈H₁₉Na₂O₈P
• 分子量: 440.292
• 精确质量: 440.061279
• PSA: 119.15000
• LogP: 4.23930
• InChIKey: SFKGCTYUWCBOHY-YSMBQZINSA-N
• SMILES: COc1ccc(C=Cc2cc(OC)c(OC)c(OC)c2)cc1OP(=O)(O)O.[Na]
• 外观性状: 白色固体
• 蒸汽压: 7.99E-16mmHg at 25°C
• 储存条件: Refrigerator
• 水溶解性: H2O: soluble5mg/mL, clear

康普瑞汀磷酸二钠安全信息

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport

康普瑞汀磷酸二钠靶点实验

查看更多实验

实验名称：Antivascular activity in HUVEC cells assessed as change in cell shape at 1 uM after 1... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL1073880

实验名称：In vitro cytotoxicity evaluated in mouse heart endotheliaoma cell (MHEC5-T) after inc... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL717396

实验名称：In vitro cytotoxicity evaluated in mouse heart endotheliaoma cell (MHEC5-T) after inc... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL717397

实验名称：Effective dose against murine P388 leukemia cell line 来源：ChEMBL 靶标：P388 External Id：CHEMBL832514

实验名称：Antitumor activity against human MDA-MB-231 xenografted in mouse assessed as tumor gr... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL1828330

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Induction of apoptosis in human HeLa cells assessed as viable cells at 0.05 uM after ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4412814

实验名称：Induction of apoptosis in human HeLa cells assessed as early apoptotic cells at 0.05 ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4412815

实验名称：Induction of apoptosis in human HeLa cells assessed as late apoptotic cells at 0.05 u... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4412816

实验名称：Induction of apoptosis in human HeLa cells assessed as necrotic cells at 0.05 uM afte... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4412817

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康普瑞汀磷酸二钠英文别名

• Fosbretabulin disodium
• Phenol, 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, dihydrogen phosphate, sodium salt (1:2)
• Fosbretabulin disodium (USAN)
• Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium
• Combretastatin A-4 phosphate
• Zybrestat
• Disodium 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]phenyl phosphate
• CA4DP
• Combretastatin A4 disodium phosphate
• Fosbretabulin (disodium)
• CoMbretastatin A4 Phosphate DisodiuM Salt