Flavokawain B

Modify Date: 2025-08-22 10:29:42

Flavokawain B Structure
Flavokawain B structure
 Common Name Flavokawain B
CAS Number 1775-97-9 Molecular Weight 284.306
Density 1.203±0.06 g/cm3 Boiling Point 500.1±50.0 °C at 760 mmHg
Molecular Formula C17H16O4 Melting Point 178-179 ºC (ethanol )
MSDS N/A Flash Point 185.8±23.6 °C

 Use of Flavokawain B


Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2].

 Names

Name 4',6'-dimethoxy-2'-hydroxychalcone
Synonym More Synonyms

 Flavokawain B Biological Activity

Description Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2].
Related Catalog
References

[1]. Rossette MC, et al. The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B. Phytother Res. 2017 Oct;31(10):1607-1613.

[2]. Li X, et al. Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation. Cell Commun Signal. 2019 Mar 18;17(1):25.

 Chemical & Physical Properties

Density 1.203±0.06 g/cm3
Boiling Point 500.1±50.0 °C at 760 mmHg
Melting Point 178-179 ºC (ethanol )
Molecular Formula C17H16O4
Molecular Weight 284.306
Flash Point 185.8±23.6 °C
Exact Mass 284.104858
PSA 55.76000
LogP 4.01
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.614
Storage condition -20℃
Water Solubility Practically insoluble (0.012 g/L) (25 ºC)

 Safety Information

HS Code 2914509090

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
CARDAMONIN-4'-METHYL ETHER
2'-Hydroxy-4',6'-dimethoxychalcone
2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-
flavokawin B
(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one
(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
1OR CQ EO1 BV1U1R &&E Form
MFCD00075877
DIMETHOXY-2'-HYDROXYCHALCONE,4',6'
Flavokawain B
Flavokavain B
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