Flavokawain B
Flavokawain B structure
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Common Name | Flavokawain B | ||
|---|---|---|---|---|
| CAS Number | 1775-97-9 | Molecular Weight | 284.306 | |
| Density | 1.203±0.06 g/cm3 | Boiling Point | 500.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H16O4 | Melting Point | 178-179 ºC (ethanol ) | |
| MSDS | N/A | Flash Point | 185.8±23.6 °C | |
Use of Flavokawain BFlavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 4',6'-dimethoxy-2'-hydroxychalcone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.203±0.06 g/cm3 |
|---|---|
| Boiling Point | 500.1±50.0 °C at 760 mmHg |
| Melting Point | 178-179 ºC (ethanol ) |
| Molecular Formula | C17H16O4 |
| Molecular Weight | 284.306 |
| Flash Point | 185.8±23.6 °C |
| Exact Mass | 284.104858 |
| PSA | 55.76000 |
| LogP | 4.01 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.614 |
| InChIKey | QKQLSQLKXBHUSO-CMDGGOBGSA-N |
| SMILES | COc1cc(O)c(C(=O)C=Cc2ccccc2)c(OC)c1 |
| Storage condition | -20℃ |
| Water Solubility | Practically insoluble (0.012 g/L) (25 ºC) |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| HS Code | 2914509090 |
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Flavokawain B CAS#:1775-97-9 |
| Literature: Singh, Om V.; Muthukrishnan; Sunderavadivelu Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 12 p. 2575 - 2581 |
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Flavokawain B CAS#:1775-97-9 |
| Literature: Pouget, Christelle; Lauthier, Fabienne; Simon, Alain; Fagnere, Catherine; Basly, Jean-Philippe; Delage, Christiane; Chulia, Albert-Jose Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 24 p. 3095 - 3097 |
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Flavokawain B CAS#:1775-97-9 |
| Literature: Seo, Young Ho; Park, Sun You Bulletin of the Korean Chemical Society, 2014 , vol. 35, # 4 p. 1154 - 1158 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
|---|---|
| DownStream 9 | |
CAS#:26964-35-2
CAS#:3187-19-7
CAS#:93-58-3
CAS#:65-85-0
CAS#:75291-74-6
CAS#:21392-57-4
CAS#:33483-23-7
CAS#:26964-29-4This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one |
| CARDAMONIN-4'-METHYL ETHER |
| 2'-Hydroxy-4',6'-dimethoxychalcone |
| flavokawin B |
| (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one |
| (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one |
| 1OR CQ EO1 BV1U1R &&E Form |
| MFCD00075877 |
| DIMETHOXY-2'-HYDROXYCHALCONE,4',6' |
| Flavokawain B |
| Flavokavain B |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: InChIKey of 4',6'-dimethoxy-2'-hydroxychalcone is QKQLSQLKXBHUSO-CMDGGOBGSA-N. |
| Q: What is the polar surface area (PSA) of 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: Polar surface area (PSA) of 4',6'-dimethoxy-2'-hydroxychalcone is 55.76000. |
| Q: What are the storage conditions for 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: Storage conditions for 4',6'-dimethoxy-2'-hydroxychalcone: -20℃. |
| Q: What are the upstream materials of 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: Related upstream materials(CAS) of 4',6'-dimethoxy-2'-hydroxychalcone: 90-24-4;100-52-7;1036-72-2;480-66-0. |
| Q: What is the SMILES notation of 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: SMILES notation of 4',6'-dimethoxy-2'-hydroxychalcone is COc1cc(O)c(C(=O)C=Cc2ccccc2)c(OC)c1. |
| Q: What is the CAS number of 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: CAS number of 4',6'-dimethoxy-2'-hydroxychalcone is 1775-97-9. |
| Q: What are the uses of 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: Main uses of 4',6'-dimethoxy-2'-hydroxychalcone: Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2]. |
| Q: What is the molecular formula of 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: Molecular formula of 4',6'-dimethoxy-2'-hydroxychalcone is C17H16O4. |
| Q: What is the boiling point of 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: Boiling point of 4',6'-dimethoxy-2'-hydroxychalcone is 500.1±50.0 °C at 760 mmHg. |
| Q: What are the downstream products of 4',6'-dimethoxy-2'-hydroxychalcone? |
| A: Related downstream products(CAS) of 4',6'-dimethoxy-2'-hydroxychalcone: 26964-35-2;3187-19-7;93-58-3;100-52-7;65-85-0;75291-74-6;21392-57-4;33483-23-7;26964-29-4. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |