Fentiazac
Modify Date: 2025-08-27 09:52:47
Fentiazac structure
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Common Name | Fentiazac | ||
|---|---|---|---|---|
| CAS Number | 18046-21-4 | Molecular Weight | 329.80100 | |
| Density | 1.362g/cm3 | Boiling Point | 556.2ºC at 760mmHg | |
| Molecular Formula | C17H12ClNO2S | Melting Point | 162ºC | |
| MSDS | N/A | Flash Point | 290.2ºC | |
Use of FentiazacFentiazac, alkanoic acid derivative, is an orally active non-steroidal anti-inflammatory agent, with analgesic, antipyretic and platelet anti-aggregation activity. Fentiazac can be used to research inflammatory diseases such as rheumatoid arthritis, osteoarthritis and tendinitis[1][2][3]. |
| Name | 2-[4-(4-chlorophenyl)-2-phenyl-1,3-thiazol-5-yl]acetic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Fentiazac, alkanoic acid derivative, is an orally active non-steroidal anti-inflammatory agent, with analgesic, antipyretic and platelet anti-aggregation activity. Fentiazac can be used to research inflammatory diseases such as rheumatoid arthritis, osteoarthritis and tendinitis[1][2][3]. |
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| Related Catalog | |
| In Vivo | Fentiazac is well tolerated after repeated oral administration in rats, monkeys and dogs; and no significant modifications in the heart and bone marrow function, as well as blood chemistry[1]. Tolerance of Fentiazac in rat, monkey and dog[1]. Species Tolerant dosage Tolerant administration day Rat 0-50 mg/kg/day 90 days Red pated monkey 40 mg/kg/day 90 days 0-30 mg/kg/day 180 days African green monkey 0-8 mg/kg/day 79 to 93 days dog 16.6 mg/kg/day 180 days |
| Density | 1.362g/cm3 |
|---|---|
| Boiling Point | 556.2ºC at 760mmHg |
| Melting Point | 162ºC |
| Molecular Formula | C17H12ClNO2S |
| Molecular Weight | 329.80100 |
| Flash Point | 290.2ºC |
| Exact Mass | 329.02800 |
| PSA | 78.43000 |
| LogP | 4.75760 |
| Vapour Pressure | 3.3E-13mmHg at 25°C |
| Index of Refraction | 1.646 |
| InChIKey | JIEKMACRVQTPRC-UHFFFAOYSA-N |
| SMILES | O=C(O)Cc1sc(-c2ccccc2)nc1-c1ccc(Cl)cc1 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Risk Phrases | 36/37/38 |
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| Precursor 2 | |
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| DownStream 0 | |
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
|
|
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
|
|
Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
|
|
Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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|
Name: Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate...
Source: ChEMBL
Target: Indoleamine 2,3-dioxygenase 2
External Id: CHEMBL2210856
|
|
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
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| Fentiazacum [INN-Latin] |
| Donorest |
| BR 700 |
| 4-(p-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid |
| Flogene |
| 2-phenyl-4-p-chlorophenylthiazol-5-ylacetic acid |
| Norvedan |
| [4-(4-chloro-phenyl)-2-phenyl-thiazol-5-yl]-acetic acid |
| Fentiazaco [INN-Spanish] |
| 4-(4-chlorophenyl)-2-phenyl-5-thiazolylacetic acid |
| Fentiazac |