3,4-Dibromo-Mal-PEG2-N-Boc

Modify Date: 2024-01-09 13:38:14

3,4-Dibromo-Mal-PEG2-N-Boc Structure
3,4-Dibromo-Mal-PEG2-N-Boc structure
Common Name 3,4-Dibromo-Mal-PEG2-N-Boc
CAS Number 1807537-43-4 Molecular Weight 486.153
Density 1.6±0.1 g/cm3 Boiling Point 513.0±50.0 °C at 760 mmHg
Molecular Formula C15H22Br2N2O6 Melting Point N/A
MSDS N/A Flash Point 264.1±30.1 °C

 Use of 3,4-Dibromo-Mal-PEG2-N-Boc


3,4-Dibromo-Mal-PEG2-N-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3,4-Dibromo-Mal-PEG2-Boc-Amine
Synonym More Synonyms

 3,4-Dibromo-Mal-PEG2-N-Boc Biological Activity

Description 3,4-Dibromo-Mal-PEG2-N-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 513.0±50.0 °C at 760 mmHg
Molecular Formula C15H22Br2N2O6
Molecular Weight 486.153
Flash Point 264.1±30.1 °C
Exact Mass 483.984436
LogP 1.57
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.558

 Synonyms

MFCD27635177
Carbamic acid, N-[2-[2-[2-(3,4-dibromo-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl (2-{2-[2-(3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl)carbamate
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