CHMFL-ABL-053
Modify Date: 2024-04-06 15:41:04
CHMFL-ABL-053 structure
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Common Name | CHMFL-ABL-053 | ||
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| CAS Number | 1808287-83-3 | Molecular Weight | 549.547 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C28H26F3N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CHMFL-ABL-053CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM; no inhibitory activity against c-Kit (>10 uM); inhibits the proliferation of CML cell lines K562 (GI50=14 nM), KU812 (GI50=25 nM), and MEG-01 (GI50=16 nM); completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model with 50 mg/kg/day dosage treatment. |
| Name | 2-[(3-Amino-4-methylphenyl)amino]-4-(methylamino)-N-(2-methyl-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-5-pyrimidinecarboxamide |
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| Synonym | More Synonyms |
| Description | CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM; no inhibitory activity against c-Kit (>10 uM); inhibits the proliferation of CML cell lines K562 (GI50=14 nM), KU812 (GI50=25 nM), and MEG-01 (GI50=16 nM); completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model with 50 mg/kg/day dosage treatment. |
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| References | References 1. Liang X, et al. J Med Chem. 2016 Mar 10;59(5):1984-2004. View Related Products by Target Bcr-Abl |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C28H26F3N7O2 |
| Molecular Weight | 549.547 |
| Exact Mass | 549.210022 |
| LogP | 4.60 |
| Index of Refraction | 1.698 |
| 5-Pyrimidinecarboxamide, 2-[(3-amino-4-methylphenyl)amino]-4-(methylamino)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]- |
| 2-[(3-Amino-4-methylphenyl)amino]-4-(methylamino)-N-(2-methyl-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-5-pyrimidinecarboxamide |