Jaceosidin

Modify Date: 2025-08-20 18:01:37

Jaceosidin Structure
Jaceosidin structure
Common Name Jaceosidin
CAS Number 18085-97-7 Molecular Weight 330.29
Density 1.5±0.1 g/cm3 Boiling Point 619.0±55.0 °C at 760 mmHg
Molecular Formula C17H14O7 Melting Point N/A
MSDS N/A Flash Point 232.0±25.0 °C

 Use of Jaceosidin


Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression[1]. Jaceosidin exhibits anti-cancer[2], anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation[3].

 Names

Name jaceosidin
Synonym More Synonyms

 Jaceosidin Biological Activity

Description Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression[1]. Jaceosidin exhibits anti-cancer[2], anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation[3].
Related Catalog
Target

Bax

COX-2

In Vitro Jaceosidin (30, 50, 75 μM) induces apoptosis in human renal carcinoma Caki cells after treatment for 24 h, shows no obvious effect on normal cells[1]. Jaceosidin (75 μM) reduces MMP levels and causes cytochrome c release into the cytoplasm through Bax activation[1]. Jaceosidin-mediated apoptosis is involved in downregulation of Mcl-1, c-FLIP expression, which is via inhibition of NF-κB and/or Sp1 transcriptional activity[1]. Jaceosidin shows cytostatic activity to HES and HESC cells with IC50s of 52.68 and 55.10 μM, and is less cytotocxic on Hec1 A and KLE (IC50, 70.54, 147.14 μM, respectively), after treatment for 48 h[2]. Cell Viability Assay[2] Cell Line: Hec1A, KLE, HES and HESC cells Concentration: 3.125, 6.25, 12.5, 25, 50, and 100 μM Incubation Time: 48 hour Result: Showed cytostatic activity to HES and HESC cells with IC50s of 52.68 and 55.10 μM, less cytotocxic on Hec1 A and KLE (IC50, 70.54, 147.14 μM).
In Vivo Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice[3]. Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice[3]. Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats[3]. Animal Model: 5-week-old male BALB/c mice (23-26 g)[3] Dosage: 10 and 20 mg/kg Administration: P.O. once a day for 3 days Result: Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation. Animal Model: Male Sprague-Dawley rats (180-200 g)[3] Dosage: 20 mg/kg Administration: P.O., for 2 hour Result: Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively.
References

[1]. Woo SM, et al. Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells. Chem Biol Interact. 2016 Dec 25;260:168-175.

[2]. Lee JG, et al. Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation. Food Chem Toxicol. 2013 May;55:214-21.

[3]. Min SW, et al. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice. J Ethnopharmacol. 2009 Sep 25;125(3):497-500.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 619.0±55.0 °C at 760 mmHg
Molecular Formula C17H14O7
Molecular Weight 330.29
Flash Point 232.0±25.0 °C
Exact Mass 330.073944
PSA 109.36000
LogP 1.30
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.671
Storage condition 2-8℃

 Safety Information

HS Code 2914509090

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

5,7,4'-trihydroxy-3',6-dimethoxyflavone
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-
5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one
5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one
5,7,4'-trihydroxy-6,3'-dimethoxyflavone
JACEOSIDINE
4',5,7-Trihydroxy-3',6-dimethoxyflavone
6-methoxyluteolin-3'-methyl ether
Jaceosidin
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.