GSK2324

Modify Date: 2024-01-05 21:11:39

GSK2324 Structure
GSK2324 structure
Common Name GSK2324
CAS Number 1020567-30-9 Molecular Weight 533.40200
Density N/A Boiling Point N/A
Molecular Formula C29H22Cl2N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GSK2324


GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC50 of 120 nM. GSK2324 exhibits t1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively[1].

 Names

Name GSK-2324
Synonym More Synonyms

 GSK2324 Biological Activity

Description GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC50 of 120 nM. GSK2324 exhibits t1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively[1].
Related Catalog
References

[1]. Jonathan Y Bass, et al. Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1206-13.  

 Chemical & Physical Properties

Molecular Formula C29H22Cl2N2O4
Molecular Weight 533.40200
Exact Mass 532.09600
PSA 85.45000
LogP 8.26420

 Synonyms

6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2-quinolinecarboxylic acid
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