MS023
Modify Date: 2024-01-09 09:34:48
MS023 structure
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Common Name | MS023 | ||
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| CAS Number | 1831110-54-3 | Molecular Weight | 287.400 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 437.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H25N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 218.6±28.7 °C | |
Use of MS023MS023 is a potent, selective, and cell-active inhibitor of human type I PRMTs with IC50 of 4-119 nM.IC50 value: 4-119 nMTarget: type I PRMTs in vitro: MS023 potently inhibits PRMT1 (IC50 = 30 ± 9 nM), PRMT3 (IC50 = 119 ± 14 nM), PRMT4 (IC50 = 83 ± 10 nM), PRMT6 (IC50 = 4 ± 0.5 nM), and PRMT8 (IC50 = 5 ± 0.1 nM). Importantly, MS023 does not inhibit any type II PRMTs (PRMT5 and 9) and type III PRMT (PRMT7) at concentrations up to 10 μM. MS023 displays high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. MS023 potently decreases cellular levels of histone arginine asymmetric dimethylation. It also reduces global levels of arginine asymmetric dimethylation and concurrently increased levels of arginine monomethylation and symmetric dimethylation in cells. [1] |
| Name | N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine |
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| Synonym | More Synonyms |
| Description | MS023 is a potent, selective, and cell-active inhibitor of human type I PRMTs with IC50 of 4-119 nM.IC50 value: 4-119 nMTarget: type I PRMTs in vitro: MS023 potently inhibits PRMT1 (IC50 = 30 ± 9 nM), PRMT3 (IC50 = 119 ± 14 nM), PRMT4 (IC50 = 83 ± 10 nM), PRMT6 (IC50 = 4 ± 0.5 nM), and PRMT8 (IC50 = 5 ± 0.1 nM). Importantly, MS023 does not inhibit any type II PRMTs (PRMT5 and 9) and type III PRMT (PRMT7) at concentrations up to 10 μM. MS023 displays high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. MS023 potently decreases cellular levels of histone arginine asymmetric dimethylation. It also reduces global levels of arginine asymmetric dimethylation and concurrently increased levels of arginine monomethylation and symmetric dimethylation in cells. [1] |
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| Related Catalog | |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 437.8±45.0 °C at 760 mmHg |
| Molecular Formula | C17H25N3O |
| Molecular Weight | 287.400 |
| Flash Point | 218.6±28.7 °C |
| Exact Mass | 287.199768 |
| LogP | 2.28 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.567 |
| Storage condition | -20℃ |
| N-{[4-(4-Isopropoxyphenyl)-1H-pyrrol-3-yl]methyl}-N-methyl-1,2-ethanediamine |
| 1,2-Ethanediamine, N-methyl-N-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]- |
| MS023 |