AMPK activator 8

Modify Date: 2024-01-23 19:17:59

AMPK activator 8 Structure
AMPK activator 8 structure
Common Name AMPK activator 8
CAS Number 1852451-96-7 Molecular Weight 480.90
Density N/A Boiling Point N/A
Molecular Formula C25H21ClN2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AMPK activator 8


AMPK activator 8 (Compound 2) is an AMP-activated protein kinase (AMPK) activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes[1].

 Names

Name AMPK activator 8

 AMPK activator 8 Biological Activity

Description AMPK activator 8 (Compound 2) is an AMP-activated protein kinase (AMPK) activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes[1].
Related Catalog
In Vitro AMPK activator 8 (compound 2) acts on rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ and rAMPK α2β2γ3 with the EC50 value of 11 nM, 27 nM, 4 nM, 2 nM and 4 nM, respectively[1]. AMPK activator 8 (compound 2) affects cell viability[1]. Cell Viability Assay[1] Cell Line: HepG2, C2C12 myoblasts Concentration: 0.01-1000 μM Incubation Time: 1 hour Result: Resulted in HepG2 and C2C12 myoblasts with the EC50 value of 255 nM and 230 nM, respectively.
References

[1]. Mathilde Muzerelle, et al. Novel activators of amp-activated protein kinases.WO2016001224A1

 Chemical & Physical Properties

Molecular Formula C25H21ClN2O6
Molecular Weight 480.90
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