PCSK9 modulator 10

Modify Date: 2024-09-08 12:21:01

PCSK9 modulator 10 Structure
PCSK9 modulator 10 structure
Common Name PCSK9 modulator 10
CAS Number 1874254-18-8 Molecular Weight 365.659
Density N/A Boiling Point N/A
Molecular Formula C15H6ClF6NO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PCSK9 modulator 10


PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM; significantly reduces LDL-c levels by 46% and 57% at 0.01 and 0.04 mg/kg in vivo without deaths or abnormal general signs.

 Names

Name PCSK9 modulator 10

 PCSK9 modulator 10 Biological Activity

Description PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM; significantly reduces LDL-c levels by 46% and 57% at 0.01 and 0.04 mg/kg in vivo without deaths or abnormal general signs.
References References 1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3. View Related Products by Target PCSK9

 Chemical & Physical Properties

Molecular Formula C15H6ClF6NO
Molecular Weight 365.659
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