P300/CBP-IN-5

Modify Date: 2024-01-11 16:07:47

P300/CBP-IN-5 structure	Common Name	P300/CBP-IN-5
	CAS Number	1889284-33-6	Molecular Weight	618.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₂₇F₅N₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of P300/CBP-IN-5

P300/CBP-IN-5 is a potent p300/CBP histone acetyltransferase inhibitor extracted from patent WO2016044770A1, Example 715, has an IC50 of 18.8 nM[1].

Name	P300/CBP-IN-5

Description	P300/CBP-IN-5 is a potent p300/CBP histone acetyltransferase inhibitor extracted from patent WO2016044770A1, Example 715, has an IC50 of 18.8 nM[1].
Related Catalog	Research Areas >> Cancer
Target	IC50: 18.8 nM (p300/CBP)[1]
In Vitro	P300/CBP-IN-5 inhibits p300 LnCap-FGC cellls proliferation with an IC50 of 14.8 nM. P300/CBP-IN-5 inhibits H3K27Ac with an IC50 value of 4.6 nM in PC-3 cells[1].
In Vivo	The effect of P300/CBP-IN-5 (Example 715) on tumor growth is evaluated in subcutaneous, SuDHL-8 (B-cell lymphoma) and 22RV1 (prostate) xenograft tumors implanted in SCID female mice. Human cancer cells are inoculated subcutaneously into the right hind flank of female SCID mice on study day 0. Administration of P300/CBP-IN-5 (7.5 mg/kg/day) is initiated at the time of size match. P300/CBP-IN-5 induces significant tumor growth inhibition in multiple xenograft tumor models (the tumor growth inhibition of 62% in SuDHL-8 xenograft tumor model; 48% in 22RV1 xenograft tumor model)[1].
References	[1]. Michael Michaelides, et al. Spirocyclic hat inhibitors and methods for their use. WO2016044770A1.

Molecular Formula	C₂₉H₂₇F₅N₆O₄
Molecular Weight	618.55

DC Chemicals Limited
China
Product Name: iP300w
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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