B-Raf IN 5

Modify Date: 2025-08-27 06:46:28

B-Raf IN 5 Structure
B-Raf IN 5 structure
Common Name B-Raf IN 5
CAS Number 2648698-30-8 Molecular Weight 583.01
Density N/A Boiling Point N/A
Molecular Formula C23H18ClF3N6O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of B-Raf IN 5


B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1].

 Names

Name B-Raf IN 5

 B-Raf IN 5 Biological Activity

Description B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1].
Related Catalog
References

[1]. Schneider M, et al. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding. J Med Chem. 2022;65(2):1552-1566.

 Chemical & Physical Properties

Molecular Formula C23H18ClF3N6O3S2
Molecular Weight 583.01
InChIKey OZNNKHBCZMWGHG-UHFFFAOYSA-N
SMILES Nc1nccc(-c2sc(C3COCCN3)nc2-c2cc(Cl)cc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.