CPI-1612

Modify Date: 2024-01-16 10:49:28

CPI-1612 Structure
CPI-1612 structure
Common Name CPI-1612
CAS Number 2374971-81-8 Molecular Weight 450.53
Density N/A Boiling Point N/A
Molecular Formula C27H26N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CPI-1612


P300/CBP-IN-6 is a p300/CBP histone acetyltransferase (HAT) inhibitor extracted from patent WO2019161162A1, compound 33, has an IC50 of 330 nM for p300 HAT[1].

 Names

Name P300/CBP-IN-6

 CPI-1612 Biological Activity

Description P300/CBP-IN-6 is a p300/CBP histone acetyltransferase (HAT) inhibitor extracted from patent WO2019161162A1, compound 33, has an IC50 of 330 nM for p300 HAT[1].
Related Catalog
Target

IC50: 330 nM (p300 HAT)[1]

In Vitro Histone acetyltransferases (HATs) catalyze the acetylation (transfer of an acetyl group) on a e-amino group of a target lysine side chain within a substrate histone, and histone deacetylases (HDACs) catalyze the removal of acetyl groups from lysine residues. Subsequently, acetylated core histones were shown to preferentially associate with transcriptionally active chromatin. HATs are categorized into four major families based on primary sequence homology, shared structural features, and functional roles: Gcn5/PCAF (General control nonrepressed protein 5 and p300 and CBP associated factor); MYST (named for the founding members MOZ, Ybf2/Sas3, Sas2, and Tip60); p300/CBP (protein of 300kDa and CREB Binding Protein); and Rttl09 (Regulator of Tyl Transposition gene production 109)[1].
References

[1]. Jonathan E. Wilson, et al. P300/cbp hat inhibitors. WO2019161162A1.

 Chemical & Physical Properties

Molecular Formula C27H26N6O
Molecular Weight 450.53
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