AP-1/NF-κB activation inhibitor 1

Modify Date: 2025-08-25 10:00:57

AP-1/NF-κB activation inhibitor 1 Structure
AP-1/NF-κB activation inhibitor 1 structure
Common Name AP-1/NF-κB activation inhibitor 1
CAS Number 188936-12-1 Molecular Weight 344.25
Density N/A Boiling Point N/A
Molecular Formula C13H11F3N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AP-1/NF-κB activation inhibitor 1


AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].

 Names

Name AP-1/NF-κB activation inhibitor 1

 AP-1/NF-κB activation inhibitor 1 Biological Activity

Description AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].
Related Catalog
References

[1]. Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;10(15):1645-1648.

 Chemical & Physical Properties

Molecular Formula C13H11F3N4O4
Molecular Weight 344.25
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