GNE-886
Modify Date: 2024-01-09 16:13:59
GNE-886 structure
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Common Name | GNE-886 | ||
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| CAS Number | 2101957-05-3 | Molecular Weight | 498.576 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 796.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C28H30N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 435.4±32.9 °C | |
Use of GNE-886GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains, >100-fold selectivity over BRD9, BRD7, TAF1(2), and BRD4(1); has a highly favorable measured kinetic solubility of 122 uM and is an appropriate in vitro tool compound for the CECR2 bromodomain. |
| Name | 6-Allyl-N-{1-[6-(3-methoxyphenyl)-4-pyrimidinyl]-4-piperidinyl}-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide |
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| Synonym | More Synonyms |
| Description | GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM; shows a wide selectivity over the 40 bromodomains, >100-fold selectivity over BRD9, BRD7, TAF1(2), and BRD4(1); has a highly favorable measured kinetic solubility of 122 uM and is an appropriate in vitro tool compound for the CECR2 bromodomain. |
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| References | References 1. Crawford TD, et al. ACS Med Chem Lett. 2017 Jun 1;8(7):737-741. View Related Products by Target Bromodomain |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 796.3±60.0 °C at 760 mmHg |
| Molecular Formula | C28H30N6O3 |
| Molecular Weight | 498.576 |
| Flash Point | 435.4±32.9 °C |
| Exact Mass | 498.237946 |
| LogP | 1.99 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.675 |
| 1H-Pyrrolo[2,3-c]pyridine-4-carboxamide, 6,7-dihydro-N-[1-[6-(3-methoxyphenyl)-4-pyrimidinyl]-4-piperidinyl]-N-methyl-7-oxo-6-(2-propen-1-yl)- |
| MFCD31556840 |
| 6-Allyl-N-{1-[6-(3-methoxyphenyl)-4-pyrimidinyl]-4-piperidinyl}-N-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-carboxamide |