4-Amino-4-deoxy-10-methylpteroic acid

Modify Date: 2024-01-02 14:01:11

4-Amino-4-deoxy-10-methylpteroic acid structure	Common Name	4-Amino-4-deoxy-10-methylpteroic acid
	CAS Number	19741-14-1	Molecular Weight	325.325
	Density	1.532	Boiling Point	689.3±65.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₅N₇O₂	Melting Point	242 ºC
	MSDS	N/A	Flash Point	370.7±34.3 °C

Use of 4-Amino-4-deoxy-10-methylpteroic acid

Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1].

Name	4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid
Synonym	More Synonyms

Description	Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate Research Areas >> Inflammation/Immunology
References	[1]. Schofield RC, et al. Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:169-75.

Density	1.532
Boiling Point	689.3±65.0 °C at 760 mmHg
Melting Point	242 ºC
Molecular Formula	C₁₅H₁₅N₇O₂
Molecular Weight	325.325
Flash Point	370.7±34.3 °C
Exact Mass	325.128723
PSA	144.14000
LogP	1.75
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.799
Storage condition	2-8°C

Hazard Codes	Xi: Irritant;
Risk Phrases	43-52/53
Safety Phrases	36/37
WGK Germany	3
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate.

Chem. Biol. 7(5) , 313-21, (2000)

Chemically induced dimerization (CID) can be used to manipulate cellular regulatory pathways from signal transduction to transcription, and to create model systems for study of the specific interactio...

An investigation into the source of the deglutamated metabolites of methotrexate in patients treated with high dose infusions.

Ann. Clin. Biochem. 23 ( Pt 2) , 210-5, (1986)

The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.

Clin. Lab. 57(7-8) , 599-606, (2011)

A modified high performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of methotrexate (MTX) and its main metabolite 7-hydroxymethotrexate (7-OHMTX) and...

Methotrexate impurity E

4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoic acid

S1584_Selleck

4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoic acid

Benzoic acid, 4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]-

4-{[(2,4-Diamino-6-pteridinyl)methyl](methyl)amino}benzoic acid

Deoxyaminopteroic acid

DAMPA

4-{[(2,4-Diaminopteridin-6-yl)methyl]methylamino}benzoic acid

4-Amino-4-deoxy-10-methylpteroic acid

Methotrexate Impurity 5

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Amino-4-deoxy-N-10-methylpteroic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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