4-Amino-4-deoxy-10-methylpteroic acid
4-Amino-4-deoxy-10-methylpteroic acid structure
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Common Name | 4-Amino-4-deoxy-10-methylpteroic acid | ||
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| CAS Number | 19741-14-1 | Molecular Weight | 325.325 | |
| Density | 1.532 | Boiling Point | 689.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C15H15N7O2 | Melting Point | 242 ºC | |
| MSDS | N/A | Flash Point | 370.7±34.3 °C | |
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Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate.
Chem. Biol. 7(5) , 313-21, (2000) Chemically induced dimerization (CID) can be used to manipulate cellular regulatory pathways from signal transduction to transcription, and to create model systems for study of the specific interactions between proteins and small-molecule chemical ligands. Ho... |
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An investigation into the source of the deglutamated metabolites of methotrexate in patients treated with high dose infusions.
Ann. Clin. Biochem. 23 ( Pt 2) , 210-5, (1986)
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The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.
Clin. Lab. 57(7-8) , 599-606, (2011) A modified high performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of methotrexate (MTX) and its main metabolite 7-hydroxymethotrexate (7-OHMTX) and compared to the immunochemical fluorescence polarization i... |
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Interference of 4-amino-4-deoxy-N10-methylpteroic acid with the radioimmunoassay of methotrexate.
Clin. Chem. 25(3) , 491-2, (1979)
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Commentary.
Clin. Chem. 56(12) , 1795-6, (2010)
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Determination of methotrexate and its metabolites 7-hydroxymethotrexate and 2,4-diamino-N10-methylpteroic acid in biological fluids by liquid chromatography with fluorimetric detection.
J. Chromatogr. A. 378(1) , 173-81, (1986) A high-performance liquid chromatographic method involving post-column cleavage and fluorimetric detection has been developed for the determination of methotrexate and its metabolites in biological fluids. The cleavage is based on photooxidative reaction of m... |
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Rapid quantitation of methotrexate and its metabolites in human serum, urine and bile, using solid-phase extraction and high-performance liquid chromatography.
J. Chromatogr. A. 487(2) , 476-82, (1989)
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High-performance liquid chromatographic assay of methotrexate, 7-hydroxymethortrexate, 4-deoxy-4-amino-N10-methylpteroic acid and sulfamethoxazole in serum, urine and cerebrospinal fluid.
J. Chromatogr. A. 231(1) , 103-10, (1982) An automated high-performance liquid chromatographic system is described for separation and quantitation of the antineoplastic drug methotrexate and metabolites, and the antibiotic sulfamethoxazole in body fluids. The 40-min analysis utilizes a reversed-phase... |
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Hepatic methotrexate content and progression of hepatic fibrosis: preliminary findings.
Ann. Rheum. Dis. 50(7) , 477-80, (1991) Liver tissue from 16 patients with rheumatoid arthritis was studied. The patients had received low dose methotrexate weekly for a minimum of 12 months between two liver biopsies. The progression of pericellular fibrosis was measured by computerised image anal... |
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Carboxypeptidase G2 rescue after high-dose methotrexate.
J. Clin. Oncol. 14(7) , 2145-9, (1996) This study was a pilot project to assess the safety and efficacy of carboxypeptidase G2 (CPG2) rescue from high-dose (HD) methotrexate (MTX) in patients with recurrent cerebral lymphoma.Four patients with recurrent primary CNS lymphoma (PCNSL) were studied. P... |