MZP-54
Modify Date: 2025-08-25 15:26:06
MZP-54 structure
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Common Name | MZP-54 | ||
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| CAS Number | 2010159-47-2 | Molecular Weight | 1036.67 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C55H66ClN7O9S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MZP-54MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. |
| Name | MZP-54 |
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| Description | MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. |
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| Related Catalog | |
| Target |
Kd: 4 nM (Brd4BD2)[1] |
| In Vitro | MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. MZP-54 binds to VHL-EloC-EloB protein (VCB) with a Kd of 105 ± 24 nM. MZP-54 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC50s of 7.08 ± 0.05 and 6.37 ± 0.03, respectively. MZP-54 also exhibits high depletion of cMyc levels[1]. |
| Cell Assay | MV4;11 or HL60 cells are incubated with MZP-54 at the desired concentration for 48 h on a clear-bottom 384-well plate. Cells are kept in RPMI medium supplemented with 10% FBS, l-glutamine, penicillin, and streptomycin. Initial cell density is 3 × 105 per mL. Cells are treated with various concentrations of MZP-54 or 0.05% DMSO. After treatment, cell viability is measured with cell viability assay kit. Signal is recorded. Data are analyzed with Graphpad Prism software to obtain EC50 values of each MZP-54[1]. |
| References |
| Molecular Formula | C55H66ClN7O9S |
|---|---|
| Molecular Weight | 1036.67 |
| Storage condition | 2-8℃ |