Clofazimine

Modify Date: 2024-01-02 20:24:25

Clofazimine structure	Common Name	Clofazimine
	CAS Number	2030-63-9	Molecular Weight	473.396
	Density	1.3±0.1 g/cm3	Boiling Point	566.9±50.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₂₂Cl₂N₄	Melting Point	210-212°
	MSDS	Chinese USA	Flash Point	296.7±30.1 °C

Use of Clofazimine

Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.

Name	clofazimine
Synonym	More Synonyms

Description	Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Dye Reagents Research Areas >> Inflammation/Immunology

Density	1.3±0.1 g/cm3
Boiling Point	566.9±50.0 °C at 760 mmHg
Melting Point	210-212°
Molecular Formula	C₂₇H₂₂Cl₂N₄
Molecular Weight	473.396
Flash Point	296.7±30.1 °C
Exact Mass	472.122162
PSA	42.21000
LogP	7.26
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.667
Water Solubility	Practically insoluble in water, soluble in methylene chloride, very slightly soluble in ethanol (96 per cent). It shows polymorphism (5.9).

Clofazimine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SG1578000

CHEMICAL NAME :: Phenazine, 2,10-dihydro-3-(p-chloroanilino)-10-(p-chlorophenyl)- 2-(isopropylimino)-

CAS REGISTRY NUMBER :: 2030-63-9

BEILSTEIN REFERENCE NO. :: 0060420

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C27-H22-Cl2-N4

MOLECULAR WEIGHT :: 473.43

WISWESSER LINE NOTATION :: T C666 BN IN EHJ BR DG& ENUY1&1 FMR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 32,911,1994

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SG1578000
HS Code	35040000

Precursor 1
CAS#:84803-71-4 1,5-bis(4-chlor...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.

Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015)

Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase th...

Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis.

Proc. Natl. Acad. Sci. U. S. A. 112(3) , 869-74, (2015)

A key drug for the treatment of leprosy, clofazimine has recently been associated with highly effective and significantly shortened regimens for the treatment of multidrug-resistant tuberculosis (TB)....

Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co-formulation.

Drug Deliv Transl Res 5 , 257-67, (2015)

Contemporary chemotherapy is limited by disseminated, resistant cancer. Targeting nanoparticulate drug delivery systems that encapsulate synergistic drug combinations are a rational means to increase ...

2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-[(1-methylethyl)imino]-

N,5-Bis(4-chlorophenyl)-3-(isopropylimino)-3,5-dihydro-2-phenazinamine

Clofaziminum [INN-Latin]

2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-((1-methylethyl)imino)-

Clofazimine

Clofaziminum

N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine

Chlofazimine

Clofazimine (N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine

Clofazimina [INN-Spanish]

Lamprene

Lampren

2-(4-chloro-anilino)-5-(4-chloro-phenyl)-3-isopropylamino-phenazinium-betaine

2-(4-Chlor-anilino)-5-(4-chlor-phenyl)-3-isopropylamino-phenazinium-betain

B 663 (Pharmaceutical)

N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine

Clofazimina

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Clofazimine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Clofazimine
Price: ￥1248.0/5g ￥208.0/1g
Purity: 98.0%
Delivery: Inquiry
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Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Clofazimine
Price: ￥Inquiry/1g
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Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Clofazimine
Price: $300.0/1g
Purity: 98.0%
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Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Clofazimine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Clofazimine 2030-63-9
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: $66/10mM*1mLinDMSO

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Clofazimine

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