Propargyl-PEG10-acid

Modify Date: 2024-01-09 19:56:09

Propargyl-PEG10-acid Structure
Propargyl-PEG10-acid structure
Common Name Propargyl-PEG10-acid
CAS Number 2055022-18-7 Molecular Weight 524.599
Density 1.1±0.1 g/cm3 Boiling Point 593.9±50.0 °C at 760 mmHg
Molecular Formula C24H44O12 Melting Point N/A
MSDS N/A Flash Point 184.2±23.6 °C

 Use of Propargyl-PEG10-acid


Propargyl-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Propargyl-PEG10-acid
Synonym More Synonyms

 Propargyl-PEG10-acid Biological Activity

Description Propargyl-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 593.9±50.0 °C at 760 mmHg
Molecular Formula C24H44O12
Molecular Weight 524.599
Flash Point 184.2±23.6 °C
Exact Mass 524.283264
LogP -2.95
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.469

 Synonyms

4,7,10,13,16,19,22,25,28,31-Decaoxatetratriacont-33-yn-1-oic acid
MFCD28976690
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