Propargyl-PEG10-Boc

Modify Date: 2024-01-10 00:05:22

Propargyl-PEG10-Boc Structure
Propargyl-PEG10-Boc structure
Common Name Propargyl-PEG10-Boc
CAS Number 2055022-22-3 Molecular Weight 580.705
Density 1.1±0.1 g/cm3 Boiling Point 592.3±45.0 °C at 760 mmHg
Molecular Formula C28H52O12 Melting Point N/A
MSDS N/A Flash Point 242.5±28.8 °C

 Use of Propargyl-PEG10-Boc


Propargyl-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Propargyl-PEG10-t-butyl ester
Synonym More Synonyms

 Propargyl-PEG10-Boc Biological Activity

Description Propargyl-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 592.3±45.0 °C at 760 mmHg
Molecular Formula C28H52O12
Molecular Weight 580.705
Flash Point 242.5±28.8 °C
Exact Mass 580.345886
LogP -1.26
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.462

 Synonyms

2-Methyl-2-propanyl 4,7,10,13,16,19,22,25,28,31-decaoxatetratriacont-33-yn-1-oate
4,7,10,13,16,19,22,25,28,31-Decaoxatetratriacont-33-yn-1-oic acid, 1,1-dimethylethyl ester
MFCD28976692
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