MC-Val-Cit-PAB-Auristatin E

Modify Date: 2025-09-17 00:48:11

MC-Val-Cit-PAB-Auristatin E Structure
MC-Val-Cit-PAB-Auristatin E structure
Common Name MC-Val-Cit-PAB-Auristatin E
CAS Number 2055896-77-8 Molecular Weight 1287.65
Density N/A Boiling Point N/A
Molecular Formula C68H108N11O13 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MC-Val-Cit-PAB-Auristatin E


MC-Val-Cit-PAB-Auristatin E has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-Auristatin E is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].

 Names

Name MC-Val-Cit-PAB-Auristatin E

 MC-Val-Cit-PAB-Auristatin E Biological Activity

Description MC-Val-Cit-PAB-Auristatin E has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-Val-Cit-PAB-Auristatin E is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].
Related Catalog
References

[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.

 Chemical & Physical Properties

Molecular Formula C68H108N11O13
Molecular Weight 1287.65
InChIKey ULBSEZSVDXRNQN-UIMDRQLBSA-O
SMILES CCC(C)C(C(CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C)C(O)c1ccccc1)OC)N(C)C(=O)C(NC(=O)C(C(C)C)[N+](C)(C)Cc1ccc(NC(=O)C(CCCNC(N)=O)NC(=O)C(NC(=O)CCCCCN2C(=O)C=CC2=O)C(C)C)cc1)C(C)C
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