THZ-P1-2
Modify Date: 2024-01-10 10:58:48
THZ-P1-2 structure
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Common Name | THZ-P1-2 | ||
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| CAS Number | 2058075-45-7 | Molecular Weight | 531.61 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H29N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of THZ-P1-2THZ-P1-2 is a potent and selective PI5P4K inhibitor. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines[1]. |
| Name | THZ-P1-2 |
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| Description | THZ-P1-2 is a potent and selective PI5P4K inhibitor. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines[1]. |
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| Related Catalog | |
| In Vitro | THZ-P1-2 (0.2-11.4 μM) exhibits approximately 75% inhibition of PI-4,5-P2 formation by PI5P4Kα and PI5P4Kγ and 50% inhibition by PI5P4Kβ at a concentration of 0.7 μM[1]. THZ-P1-2 (10-100000 nM; 72 hours) shows modest anti-proliferative activity in all six AML/ALL cell lines with IC50 values in the low micromolar range[1]. Cell Proliferation Assay[1] Cell Line: THP1, SEMK2, OCI/AML-2, HL60, SKM1, NOMO1 cells Concentration: 10-100000 nM Incubation Time: 72 hours Result: Showed anti-proliferative activity in all six AML/ALL cell lines with IC50 values ranging from 0.87 to 3.95 μM. |
| References |
| Molecular Formula | C31H29N7O2 |
|---|---|
| Molecular Weight | 531.61 |