Lenalidomide-Br

Modify Date: 2024-01-13 13:06:53

Lenalidomide-Br Structure
Lenalidomide-Br structure
Common Name Lenalidomide-Br
CAS Number 2093387-36-9 Molecular Weight 323.14
Density N/A Boiling Point N/A
Molecular Formula C13H11BrN2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lenalidomide-Br


Lenalidomide-Br (Compound 41) is the Lenalidomide-based ligand. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

 Names

Name Lenalidomide-Br

 Lenalidomide-Br Biological Activity

Description Lenalidomide-Br (Compound 41) is the Lenalidomide-based ligand. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
Related Catalog
References

[1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17.

[2]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

 Chemical & Physical Properties

Molecular Formula C13H11BrN2O3
Molecular Weight 323.14
Storage condition 2-8℃