CPTH2 hydrochloride
Modify Date: 2024-01-07 13:37:41
CPTH2 hydrochloride structure
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Common Name | CPTH2 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 2108899-91-6 | Molecular Weight | 328.260 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H15Cl2N3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CPTH2 hydrochlorideCPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2]. |
| Name | CPTH2 (hydrochloride) |
|---|---|
| Synonym | More Synonyms |
| Description | CPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2]. |
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| Related Catalog | |
| Target |
GCN5 p300 |
| In Vitro | CPTH2 (100 μM; 12, 24, 48 hours) hydrochloride causes a decrease in cell proliferation after as early as 12 h with a further significant reduction after 48 h stimulation[1]. CPTH2 (100 μM; 12 or 48 hours) hydrochloride causes a comparable drop of the activity in both cell lines[1]. CPTH2 (100 μM; 48 hours) hydrochloride produces a drastic increase in apoptotic/dead cell population after 48 h[1]. CPTH2 (100 μM; 12, 24, 48 hours) hydrochloride shows a reduced acetylation of both global AcH3 histone and H3AcK18[1]. CPTH2 (100 μM; 24, 48 hours) hydrochloride is capable to counteract invasion and migration of ccRCC-786-O cells in culture[1]. CPTH2 (0.2, 0.5, 1 mM) hydrochloride inhibits the growth of a GCN5 deleted strain and a single catalytic mutant E173H[2]. CPTH2 (0.6, 0.8 mM; for 24 hours) hydrochloride inhibits histone H3 acetylation in yeast cell cultures[2]. CPTH2 hydrochloride inhibits the Gcn5p dependent functional network[2]. Cell Proliferation Assay[1] Cell Line: Papillary thyroid (K1) and clear cell Renal Cell Carcinoma (ccRCC-786-O) cell lines Concentration: 100 μM Incubation Time: 12, 24, 48 hours Result: Caused a decrease in cell proliferation after as early as 12 h with a further significant reduction after 48 h stimulation. Cell Viability Assay[1] Cell Line: K1 and ccRCC-786-O cell lines Concentration: 100 μM Incubation Time: 24 hours (K1 cell) and 48 hours (ccRCC-786-O cell) Result: Caused a comparable drop of the activity in both cell lines. Apoptosis Analysis[1] Cell Line: ccRCC-786-O cells Concentration: 100 μM Incubation Time: 48 hours Result: Produced a drastic increase in apoptotic/dead cell population after 48 h. Western Blot Analysis[1] Cell Line: ccRCC-786-O cells Concentration: 100 μM Incubation Time: 12, 24, 48 hours Result: Showed a reduced acetylation of both global AcH3 histone and H3AcK18. |
| References |
| Molecular Formula | C14H15Cl2N3S |
|---|---|
| Molecular Weight | 328.260 |
| Exact Mass | 327.036377 |
| Hazard Codes | Xi |
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| 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazino)-1,3-thiazole hydrochloride (1:1) |
| Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone, hydrochloride (1:1) |
| CPTH2 (hydrochloride) |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: CPTH2 (hydrochloride)
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: CPTH2 hydrochloride
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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