WY-135

Modify Date: 2024-04-13 18:12:28

Use of WY-135

WY-135 is a ALK (IC50=1.4 nM) and ROS1 (IC50=1.1 nM) dual inhibitor.

Name	WY-135

Description	WY-135 is a ALK (IC50=1.4 nM) and ROS1 (IC50=1.1 nM) dual inhibitor.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Target	IC50: 1.4 nM (ALK), 1.1 nM (ROS1)[1]
References	[1]. Wang Y, et al. Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R. Eur J Med Chem. 2018 Jan 1;143:123-136.

Molecular Formula	C₂₈H₃₄ClN₉O₃S
Molecular Weight	612.15

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